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Table 3 Multivariate analysis of risk factors for LRR and DM in 1521 patients without PMRT

From: Effectiveness of the AJCC 8th edition staging system for selecting patients with T1–2N1 breast cancer for post-mastectomy radiotherapy: a joint analysis of 1986 patients from two institutions

  LRR p DM p
HR (95% CI) HR (95% CI)
Age (≤40 vs. >40) 1.75 (1.16–2.66) .008 1.69 (1.21–2.36) 0.002
Tumor location (inner quadrant vs. non-inner quadrant) 1.92 (1.32–2.79) .001 1.48 (1.09–2.01) 0.012
Positive lymph node (2–3 vs. 1) 1.73 (1.21–2.47) .003   
Lympho-vascular invasion (yes vs. no)    1.44 (0.97–2.16) 0.074
Stage (AJCC 8th ed.)
 Ia Reference   Reference  
 Ib-IIa 2.10 (1.23–3.56) .006 1.45 (1.01–2.08) 0.044
 IIb-IIIa 5.95 (3.46–10.24) < .001 3.34 (2.26–4.93) <  0.001
  1. Abbreviations: LRR loco-regional recurrence, DM distance metastasis, HR hazard ratio, CI confidence interval, AJCC 8th ed. American Joint Committee on Cancer Staging Manual, 8th edition