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Table 2 Univariate analysis of risk factors for LRR and DM in 1521 patients without PMRT

From: Effectiveness of the AJCC 8th edition staging system for selecting patients with T1–2N1 breast cancer for post-mastectomy radiotherapy: a joint analysis of 1986 patients from two institutions

  5-year LRR % (events) p 5-year DM % (events) p
Treatment era   .521   0.446
 1/2000–12/2009 7.2 (83)   9.9 (137)  
 1/2010–12/2014 6.0 (44)   8.7 (66)  
Age (years)   .012   0.003
  ≤ 40 11.1 (29)   14.2 (44)  
  > 40 5.9 (98)   8.5 (159)  
Tumor location   .003   0.025
 Inner quadrant 10.7 (42)   11.5 (59)  
 Other quadrants 5.3 (82)   8.5 (141)  
 Unknown     
Stage (AJCC 8th ed.)   < .001   <  0.001
 IA 2.5 (18)   4.9 (43)  
 IB- IIA 6.1 (60)   8.1 (95)  
 IIB- IIIA 16.7 (49)   21.9 (65)  
No. of nodes dissected   .144   0.134
  < 10 10.3 (10)   13.9 (14)  
  ≥ 10 6.4 (117)   9.1 (189)  
No. of positive nodes   .001   0.059
 1 5.7 (55)   8.7 (102)  
 2–3 7.9 (72)   10.1 (101)  
Lympho-vascular invasion   .226   0.042
 Yes 7.7 (17)   15.7 (28)  
 No 6.5 (110)   8.6 (175)  
Histological grade   .044   0.461
 I 1.6 (1)   9.3 (8)  
 II 6.1 (81)   8.1 (128)  
 III 8.7 (45)   11.9 (67)  
T stage   < .001   <  0.001
 T1 3.7 (35)   6.8 (76)  
 T2 9.7 (92)   11.9 (127)  
Estrogen receptor   < .001   <  0.001
 Positive 5.0 (81)   6.7 (131)  
 Negative 12.0 (46)   17.8 (72)  
Progesterone receptor   < .001   <  0.001
 Positive 4.6 (74)   6.4 (126)  
 Negative 13.1 (53)   18.4 (77)  
HER2   .685   0.519
 Positive 7.7 (9)   8.4 (10)  
 Negative 6.6 (118)   9.4 (193)  
  1. Abbreviations: LRR loco-regional recurrence, DM distant metastasis, PMRT post-mastectomy radiotherapy, AJCC 8th ed. American Joint Committee on Cancer Staging Manual, 8th edition