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Table 3 Multivariate analysis for overall survival

From: Log odds of positive lymph nodes is prognostically equivalent to lymph node ratio in non-metastatic colon cancer

Variable

Multivariate analysis

HR (95% CI)

p - value

HR (95% CI)

p - value

1st episode (n = 856)

Sex

Male

 

 

Female

 

 

Age (yrs)

< 60

 

 

60–79

 

 

80+

6.208 (2.204, 17.484)

< 0.001

  

All episodes (n = 862)

LNR

 

LODDS

 

Tumour site

Caecum

 

 

Ascending colon

 

 

Hepatic flexure

0.212 (0.046, 0.980)

0.047

0.200 (0.043, 0.922)

0.039

Transverse colon

 

 

Splenic flexure

 

 

Descending colon

 

 

Sigmoid colon

0.092 (0.020, 0.421)

0.002

0.079 (0.017, 0.368)

0.001

Rectosigmoid

 

 

T stage

0–2

 

 

3

 

 

4

8.92 (3.520, 22.605)

< 0.001

8.57 (3.394, 21.655)

< 0.001

N stage

0

 

-*

 

-*

1

 

-*

 

-*

2

 

-*

 

-*

ASA

1

 

-*

 

-*

2

 

-*

 

-*

3

 

-*

 

-*

4

 

-*

 

-*

Pathological grade

Undifferentiated

 

 

Poor differentiation

 

 

Moderate differentiation

 

 

Well differentiated

 

 

LVI

No

 

 

Yes

 

 

CRM

Negative > 1 mm

 

 

Positive ≤1 mm

 

 

Not reported

 

 

≥12 LNY

No

 

 

Yes

0.423 (0.220, 0.813)

0.010

0.382 (0.199, 0.734)

0.004

  1. ASA American Society of Anesthesiologists, CI Confidence interval, CRM Circumferential margin, LNR Lymph node ratio, LNY Lymph node yield, LODDS Log odds of positive lymph nodes, LVI Lymphovascular invasion.
  2. * omitted due to collinearity