Table 2 Univariate analysis for overall survival
Variable | Univariate analysis | ||
|---|---|---|---|
HR (95% CI) | p-value | ||
1st episode (n = 856) | |||
Sex | Male | Reference group | |
Female | 0.788 (0.466, 1.332) | 0.37 | |
Age (yrs) | < 60 | Reference group | |
60–79 | 1.462 (0.492, 4.345) | 0.494 | |
80+ | 6.129 (2.177, 17.257) | < 0.001 | |
All episodes (n = 862) | |||
Tumour site | Caecum | Reference group | |
Ascending colon | 0.961 (0.484, 1.908) | 0.910 | |
Hepatic flexure | 0.372 (0.085, 1.627) | 0.189 | |
Transverse colon | 0.757 (0.340, 1.686) | 0.495 | |
Splenic flexure | 0.450 (0.103, 1.968) | 0.289 | |
Descending colon | 0.596 (0.136, 2.607) | 0.492 | |
Sigmoid colon | 0.080 (0.018, 0.350) | < 0.001 | |
Rectosigmoid | 0.534 (0.194, 1.469) | 0.224 | |
T stage | 0–2 | Reference group | |
3 | 2.501 (1.221, 5.123) | 0.012 | |
4 | 10.032 (4.529, 22.221) | < 0.001 | |
N stage | 0 | Reference group | |
1 | 0.878 (0.408, 1.891) | 0.740 | |
2 | 2.852 (1.483, 5.487) | 0.002 | |
ASA | 1 | Reference group | |
2 | 3.843 (0.884, 16.715) | 0.073 | |
3 | 8.702 (2.059, 36.767) | 0.003 | |
4 | 30.668 (6.918, 135.948) | < 0.001 | |
Pathological grade | Undifferentiated | < 0.001 (< 0.001, < 0.001) | 0.996 |
Poor differentiation | 2.43 (1.415, 4.168) | 0.001 | |
Moderate differentiation | Reference group | ||
Well differentiated | 0.515 (0.070, 3.776) | 0.514 | |
LVI | No | Reference group | |
Yes | 1.916 (1.124, 3.264) | 0.017 | |
CRM | Negative > 1 mm | Reference group | |
Positive ≤1 mm | 2.838 (0.382, 21.084) | 0.31 | |
Not reported | 0.764 (0.441, 1.322) | 0.34 | |
≥ 12 LNY | No | Reference group | |
Yes | 0.803 (0.449, 1.435) | 0.46 | |
LNR groups | < 0.05 | Reference group | |
0.05 to < 0.2 | 0.732 (0.287, 1.867) | 0.51 | |
≥ 0.2 | 3.775 (2.063, 6.908) | < 0.001 | |
LODDS | <−1.36 | Reference group | |
−1.36 to −0.53 | 0.852 (0.428, 1.695) | 0.65 | |
> 0.53 | 3.715 (1.974, 6.991) | < 0.001 | |