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Table 1 Patient and tumour characteristics and 5-year overall survival

From: Log odds of positive lymph nodes is prognostically equivalent to lymph node ratio in non-metastatic colon cancer

Variable

 

N (%)

5-year OS (95% CI)

p-value

N (1st episode)

 

n = 856

  

Sex

Male

402 (47.0)

82 (73.5, 91.5)

0.4

Female

454 (53.0)

86 (80.2, 92.2)

 

Age at first surgery

< 60

146 (17.1)

91.5 (82.9, 100)

< 0.001

60–79

424 (49.5)

91.3 (87.1, 95.7)

 

≥ 80

286 (33.4)

65.4 (51.1, 83.7)

 

N (All episodes)

 

n = 862

  

Tumour site

Caecum

143 (16.6)

77.4 (67.4, 89)

< 0.001

Ascending colon

172 (20.0)

69 (51.4, 92.6)

 

Hepatic flexure

61 (7.1)

92.4 (82.8, 100)

 

Transverse colon

130 (15.1)

83 (72.9, 94.6)

 

Splenic flexure

43 (5.0)

n/a

 

Descending colon

33 (3.8)

n/a

 

Sigmoid colon

217 (25.2)

98.9 (97.3, 100)

 

Rectosigmoid

63 (7.3)

82.8 (68.6, 100)

 

T stage

0–2

327 (37.9)

93.3 (88.9, 97.9)

< 0.001

3

451 (52.3)

80.4 (71.5, 90.4)

 

4

84 (9.7)

n/a

 

N stage

0

619 (71.8)

85.2 (79, 91.9)

0.01

1

165 (19.1)

85.3 (74.2, 98.1)

 

2

78 (9.0)

71.2 (57.4, 88.4)

 

ASA

1

151 (17.5)

95.9 (90.0, 100)

< 0.001

2

348 (40.4)

91.0 (86.6, 95.7)

 

3

315 (36.5)

73.7 (60.2, 90.3)

 

4

47 (5.5)

46.1 (28.9, 73.6)

 

Pathological grade

Undifferentiated

5 (0.6)

n/a

0.009

Poor differentiation

164 (19.0)

74.7 (64.5, 86.6)

 

Moderate differentiation

579 (67.2)

85.3 (78.1, 93)

 

Well differentiated

47 (5.5)

91.7 (77.3, 100)

 

LVI

No

591 (68.6)

84.9 (78.5, 91.8)

0.02

Yes

244 (28.3)

81.7 (74.6, 89.4)

 

CRM

Negative > 1 mm

465 (53.9)

79.6 (69.3, 91.4)

0.4

Positive ≤1 mm

8 (0.9)

n/a

 

Not reported

375 (43.5)

86.6 (81.8, 91.6)

 

LNY

<12

168 (19.5)

85.4 (78.6, 92.9)

0.5

≥12

694 (80.5)

83.4 (76.7, 90.6)

 

LNR groups

< 0.05

655 (76.0)

85.8 (79.8, 92.3)

< 0.001

0.05 to < 0.2

128 (14.8)

90.7 (82.8, 99.4)

 

≥0.2

78 (9.0)

61.3 (45.3, 82.9)

 

LODDS

<−1.36

569 (66.0)

84.5 (77.6, 92.1)

< 0.001

−1.36 to −0.53

217 (25.2)

91.0 (85.7, 96.6)

 

> − 0.53

75 (8.7)

61.1 (44.9, 83.2)

 
  1. ASA American Society of Anesthesiologists, CI Confidence interval, CRM Circumferential margin, LNR Lymph node ratio, LNY Lymph node yield, LODDS Log odds of positive lymph nodes, LVI Lymphovascular invasion, OS Overall survival.