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Fig. 1 | BMC Cancer

Fig. 1

From: Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma

Fig. 1

HIC, Western blot analysis and mtDNA damage quantification in human HCC samples. a Representative images of non-tumor, Grades 1, 2 and 3 samples stained with hematoxylin/eosin (20x) (upper panel) and APE1 (20x) (lower panel). b Graph showing the percentage of APE1’s cytoplasmic positive cells in tumor tissues. c Graph showing the relative levels of mtDNA damage of tumor tissue with respect to the distal non-tumor area of the same patient. d Representative Western blot analyses of nuclear and mitochondrial protein extracts of Grades 1–2 and Grade 3 tumor samples (upper panel). The graphs (lower panel) show the relative amounts of Mia40 and APE1 in the tumor tissues (Tumor) with respect to the distal non-tumor area (Distal) of the same patient. Anti-LSD1 antibodies and anti-ATP5A proteins were used as nuclear and mitochondrial markers, respectively. Full-length blots are presented in Supplementary Figure 1. (*: p < 0.05)

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BMC Cancer

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