From: Clinical effects of curcumin in enhancing cancer therapy: A systematic review
Author’s name, year | Country | Duration of study | Dosage of the drug | Number of patients | Results |
---|---|---|---|---|---|
Hejazi,2013 [35] | Iran | 2 years | 3 g per day | 40 | Curcumin reduces the severity of urinary symptoms. |
Belcaro,2014 [36] | Italy | – | 500 mg with soy lecithin | 80 | Curcumin reduced side effects. |
Bayet-robert,2010 [37] | France | 16 months | 500 to 600 mg | 10 | Curcumin lowers the concentration of the CEA marker tumor. |
Ryam,2013 [38] | USA | 2 years | 6 g | 30 | Curcumin reduces some skin complications. |
Kanai,2011 [39] | Japan | 11 months | 8 g | 22 | Curcumin increased patient survival. |
Hemati,2011 [40] | Iran | 6 months | 6 g | 40 | Curcumin reduces some skin problems. |
Garcea,2005 [41] | UK | – | 450 to 1800 mg per day | 12 | Curcumin increased the effectiveness of the colon. |
Sharma,2001 [42] | UK | 4 months | 0.18–0.036 g per day | 15 | Curcumin reduced glutathione s-transferase activity. |
Sharma,2004 [43] | UK | 4 months | 3.6–0.45 g per day | 15 | Curcumin reduces prostaglandin E2 production. |
Cruz-correa M,2006 [44] | USA | 5 months | 1.44 g per day | 10 | Reduces the number and size of polyps without any significant toxicity. |
Yu He,2010 [45] | China | 10–30 days | 1.08 g per day | 126 | Curcumin has been shown to improve the overall health of patients with colorectal cancer. |
Durgaprasad,2005 [46] | India | 6 Weeks | 1.5 g per day | 20 | Curcumin reduced lipid peroxidation and increased glutathione content in patients. |
Dhillon,2008 [47] | USA | – | 8 g per day | 25 | Well-tolerated, limited absorption, and showed activity in some patients |
Ide,2010 [48] | Japan | 6 months | 0.1 g per day | 85 | Reduced the serum prostate-specific antigen content in combination with isoflavones |
Golombick,2009 [49] | Australia | 6 months | 4 g per day | 26 | Decreased para protein load and urinary N telopeptide of type I collagen |
Polasa,1992 [50] | India | 30 days | 1.5 g per day | 16 | Reduced the urinary excretion of mutagens in smokers |
Hastak,1997 [51] | India | 3 months | 3.6 g per day | 26 | Reduced the number of micronuclei in mucosal cells and in circulating lymphocytes |
Cheng,2001 [52] | Taiwan | 3 months | 8 g per day | 25 | Improved the precancerous lesions |
Rai,2010 [53] | UK | 7 days | 1 g per day | 75 | Increased vitamins C and E levels, decrease dmalondi aldehyde and 8-hydroxy deoxy guanosine contents in the serum and saliva |
Marcia Cruz Correa,2018 [54] | New York | 12 month | 1500 mg orally, twice a day | 44 | No difference in polyp size and number between placebo and curcumin |
Richard Greil,2018 [55] | USA | 8 weeks | Doses between 100 and 300 mg per minute | 32 | No variation in tumor size according to RECIST criteria |
Lynne M Howells,2019 [56] | United Kingdom | 291 days | 2 g per day | 24 | Curcumin was a safe and tolerable adjunct to FOLFOX chemotherapy in patients with metastatic colorectal cancer |