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Table 1 examines the characteristics extracted in the studies

From: Clinical effects of curcumin in enhancing cancer therapy: A systematic review

Author’s name, year

Country

Duration of study

Dosage of the drug

Number of patients

Results

Hejazi,2013 [35]

Iran

2 years

3 g per day

40

Curcumin reduces the severity of urinary symptoms.

Belcaro,2014 [36]

Italy

–

500 mg with soy lecithin

80

Curcumin reduced side effects.

Bayet-robert,2010 [37]

France

16 months

500 to 600 mg

10

Curcumin lowers the concentration of the CEA marker tumor.

Ryam,2013 [38]

USA

2 years

6 g

30

Curcumin reduces some skin complications.

Kanai,2011 [39]

Japan

11 months

8 g

22

Curcumin increased patient survival.

Hemati,2011 [40]

Iran

6 months

6 g

40

Curcumin reduces some skin problems.

Garcea,2005 [41]

UK

–

450 to 1800 mg per day

12

Curcumin increased the effectiveness of the colon.

Sharma,2001 [42]

UK

4 months

0.18–0.036 g per day

15

Curcumin reduced glutathione s-transferase activity.

Sharma,2004 [43]

UK

4 months

3.6–0.45 g per day

15

Curcumin reduces prostaglandin E2 production.

Cruz-correa M,2006 [44]

USA

5 months

1.44 g per day

10

Reduces the number and size of polyps without any significant toxicity.

Yu He,2010 [45]

China

10–30 days

1.08 g per day

126

Curcumin has been shown to improve the overall health of patients with colorectal cancer.

Durgaprasad,2005 [46]

India

6 Weeks

1.5 g per day

20

Curcumin reduced lipid peroxidation and increased glutathione content in patients.

Dhillon,2008 [47]

USA

–

8 g per day

25

Well-tolerated, limited absorption, and showed activity in some patients

Ide,2010 [48]

Japan

6 months

0.1 g per day

85

Reduced the serum prostate-specific antigen content in combination with isoflavones

Golombick,2009 [49]

Australia

6 months

4 g per day

26

Decreased para protein load and urinary N telopeptide of type I collagen

Polasa,1992 [50]

India

30 days

1.5 g per day

16

Reduced the urinary excretion of mutagens in smokers

Hastak,1997 [51]

India

3 months

3.6 g per day

26

Reduced the number of micronuclei in mucosal cells and in circulating lymphocytes

Cheng,2001 [52]

Taiwan

3 months

8 g per day

25

Improved the precancerous lesions

Rai,2010 [53]

UK

7 days

1 g per day

75

Increased vitamins C and E levels, decrease dmalondi aldehyde and 8-hydroxy deoxy guanosine contents in the serum and saliva

Marcia Cruz Correa,2018

[54]

New York

12 month

1500 mg orally, twice a day

44

No difference in polyp size and number between placebo and curcumin

Richard Greil,2018 [55]

USA

8 weeks

Doses between 100 and 300 mg per minute

32

No variation in tumor size according to RECIST criteria

Lynne M Howells,2019 [56]

United Kingdom

291 days

2 g per day

24

Curcumin was a safe and tolerable adjunct to FOLFOX chemotherapy in patients with metastatic colorectal cancer