Table 3 Univariate analysis of prognostic factors for overall survival (OS) and disease-free survival (DFS) in matched cohort
Variables | Numbers | 5-year OS (%) | P value | 5-year DFS (%) | P value |
|---|---|---|---|---|---|
Sex | |||||
Male | 104 | 83.4 | 0.607 | 84.4 | 0.057 |
Female | 94 | 79.4 | 72.4 | ||
Age(y) | |||||
≤60 | 112 | 89.7 | 0.001 | 84.8 | 0.010 |
>60 | 86 | 71.3 | 70.3 | ||
ASA | |||||
I | 102 | 84.9 | 0.293 | 84.4 | 0.036 |
II- III | 96 | 78.3 | 72.3 | ||
BMI (kg/m2) | |||||
<25 | 107 | 77.3 | 0.074 | 79.7 | 0.986 |
≥25 | 91 | 86.7 | 77.7 | ||
Location | |||||
Mid/high | 99 | 86.4 | 0.033 | 86.2 | 0.017 |
Low | 99 | 77.0 | 71.2 | ||
Preoperative CEA (ng/ml) | |||||
≤5 | 137 | 82.6 | 0.043 | 82.2 | 0.141 |
>5 | 61 | 79.1 | 71.4 | ||
Preoperative CA19–9 (U/ml) | |||||
≤37 | 180 | 84.0 | 0.006 | 80.6 | 0.019 |
>37 | 18 | 58.8 | 60.2 | ||
Preoperative CA72.4 (U/ml) | |||||
≤6.7 | 175 | 82.2 | 0.543 | 79.1 | 0.436 |
>6.7 | 23 | 78.0 | 75.6 | ||
Tumor differentiation | |||||
Well/moderate | 159 | 84.3 | 0.079 | 79.1 | 0.915 |
Poor | 39 | 71.0 | 76.9 | ||
Pathological T stage | |||||
pT0–2 | 73 | 92.0 | 0.008 | 85.2 | 0.288 |
pT3–4 | 125 | 75.6 | 74.7 | ||
Pathological N stage | |||||
pN0 | 98 | 94.2 | <0.001 | 86.0 | 0.026 |
pN1–2 | 100 | 68.9 | 71.2 | ||
Lymphovascular invasion | |||||
Negative | 174 | 86.7 | <0.001 | 80.3 | 0.118 |
Positive | 24 | 46.7 | 65.5 | ||
Perineural invasion | |||||
Negative | 195 | 82.0 | 0.192 | 79.0 | 0.200 |
Positive | 3 | 50.0 | 50.0 | ||
Type of operation | |||||
Restorative | 127 | 86.2 | 0.225 | 81.3 | 0.235 |
Non-restorative | 71 | 73.5 | 73.8 | ||
Harvested lymph nodes | |||||
≥12 | 139 | 82.4 | 0.632 | 82.6 | 0.018 |
<12 | 59 | 80.2 | 69.6 | ||
Distal resection margin (cm) | |||||
≥1 | 187 | 81.7 | 0.871 | 77.5 | 0.096 |
<1 | 11 | 80.8 | 100.0 | ||
CRM (mm) | |||||
>1 | 192 | 81.7 | 0.310 | 80.2 | <0.001 |
≤1 | 6 | 80.0 | 33.3 | ||
Operative complications | |||||
No | 174 | 84.8 | 0.003 | 79.7 | 0.569 |
Yes | 24 | 59.5 | 71.9 | ||
Reoperation | |||||
No | 193 | 82.3 | 0.121 | 78.1 | 0.263 |
Yes | 5 | 60.0 | 100.0 | ||
Neoadjuvant therapy | |||||
No | 143 | 82.4 | 0.519 | 81.9 | 0.035 |
Yes | 55 | 80.2 | 70.2 | ||
Adjuvant chemotherapy | |||||
No | 82 | 79.2 | 0.882 | 82.4 | 0.310 |
Yes | 116 | 83.3 | 76.2 | ||