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Table 1 Standard Protocol Items for Intervention Trials (SPIRIT): schedule of enrollment, interventions and repeated measurements. ACT: adjuvant chemotherapy; ctDNA: circulating tumor DNA; QoL: quality of life. * Intervention group only. ** Intervention group only, if ctDNA is positive

From: Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study