TY - JOUR AU - El Ansari, Fatima Zahra AU - Jouali, Farah AU - Marchoudi, Nabila AU - Bennani, Mohcine Mechita AU - Ghailani, Naima Nourouti AU - Barakat, Amina AU - Fekkak, Jamal PY - 2020 DA - 2020/08/10 TI - Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC) JO - BMC Cancer SP - 747 VL - 20 IS - 1 AB - Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as high penetrance genes of this syndrome. The identification of BRCA1/2 genetic alterations before cancer development, grant patients the chance to benefit from various medical cancer prevention approaches. Therefore, the appearance of recent advanced technologies in molecular analysis such as next generation sequencing has simplified full BRCA1/2 analysis. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-020-07250-0 DO - 10.1186/s12885-020-07250-0 ID - El Ansari2020 ER -