TY - JOUR AU - Siegel, R. L. AU - Miller, K. D. AU - Jemal, A. PY - 2019 DA - 2019// TI - Cancer statistics, 2019 JO - CA Cancer J Clin VL - 69 ID - Siegel2019 ER - TY - BOOK PY - 2019 DA - 2019// TI - Clinical practice guidelines in oncology (NCCN guidelines). Non-small cell lung Cancer. Version 4.2019 PB - National Comprehensive Cancer Network CY - Fort Washington ID - ref2 ER - TY - JOUR AU - Novello, S. AU - Barlesi, F. AU - Califano, R. AU - Cufer, T. AU - Ekman, S. AU - Levra, M. G. PY - 2016 DA - 2016// TI - Metastatic non-small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up JO - Ann Oncol VL - 27 ID - Novello2016 ER - TY - JOUR AU - Cao, M. AU - Chen, W. PY - 2019 DA - 2019// TI - Epidemiology of lung cancer in China JO - Thorac Cancer VL - 10 ID - Cao2019 ER - TY - JOUR AU - Soria, J. C. AU - Ohe, Y. AU - Vansteenkiste, J. AU - Reungwetwattana, T. AU - Chewaskulyong, B. AU - Lee, K. H. PY - 2018 DA - 2018// TI - Osimertinib in untreated EGFR-mutated advanced non-small-cell lung Cancer JO - N Engl J Med VL - 378 ID - Soria2018 ER - TY - JOUR AU - Gaspar, L. AU - Scott, C. AU - Rotman, M. AU - Asbell, S. AU - Phillips, T. AU - Wasserman, T. PY - 1997 DA - 1997// TI - Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials JO - Int J Radiat Oncol Biol Phys VL - 37 ID - Gaspar1997 ER - TY - JOUR AU - Lu, Y. AU - Fan, Y. PY - 2016 DA - 2016// TI - Combined action of EGFR tyrosine kinase inhibitors and whole-brain radiotherapy on EGFR-mutated non-small-cell lung cancer patients with brain metastasis JO - Onco Targets Ther VL - 9 ID - Lu2016 ER - TY - JOUR AU - Soffietti, R. AU - Chiavazza, C. AU - Ruda, R. PY - 2017 DA - 2017// TI - Imaging and clinical end points in brain metastases trials JO - CNS Oncol VL - 6 ID - Soffietti2017 ER - TY - JOUR AU - Suteu, P. AU - Fekete, Z. AU - Todor, N. AU - Nagy, V. PY - 2019 DA - 2019// TI - Survival and quality of life after whole brain radiotherapy with 3D conformal boost in the treatment of brain metastases JO - Med Pharm Rep VL - 92 ID - Suteu2019 ER - TY - JOUR AU - Schwartz, L. H. AU - Litiere, S. AU - Vries, E. AU - Ford, R. AU - Gwyther, S. AU - Mandrekar, S. PY - 2016 DA - 2016// TI - RECIST 1.1-update and clarification: from the RECIST committee JO - Eur J Cancer VL - 62 ID - Schwartz2016 ER - TY - JOUR AU - Trotti, A. AU - Colevas, A. D. AU - Setser, A. AU - Rusch, V. AU - Jaques, D. AU - Budach, V. PY - 2003 DA - 2003// TI - CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment JO - Semin Radiat Oncol VL - 13 ID - Trotti2003 ER - TY - JOUR AU - Sperduto, P. W. AU - Kased, N. AU - Roberge, D. AU - Xu, Z. AU - Shanley, R. AU - Luo, X. PY - 2012 DA - 2012// TI - Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases JO - J Clin Oncol VL - 30 ID - Sperduto2012 ER - TY - JOUR AU - Shin, D. Y. AU - Na, I. I. AU - Kim, C. H. AU - Park, S. AU - Baek, H. AU - Yang, S. H. PY - 2014 DA - 2014// TI - EGFR mutation and brain metastasis in pulmonary adenocarcinomas JO - J Thorac Oncol VL - 9 ID - Shin2014 ER - TY - JOUR AU - Lee, Y. J. AU - Park, I. K. AU - Park, M. S. AU - Choi, H. J. AU - Cho, B. C. AU - Chung, K. Y. PY - 2009 DA - 2009// TI - Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma JO - J Cancer Res Clin Oncol VL - 135 ID - Lee2009 ER - TY - JOUR AU - Iuchi, T. AU - Shingyoji, M. AU - Itakura, M. AU - Yokoi, S. AU - Moriya, Y. AU - Tamura, H. PY - 2015 DA - 2015// TI - Frequency of brain metastases in non-small-cell lung cancer, and their association with epidermal growth factor receptor mutations JO - Int J Clin Oncol VL - 20 ID - Iuchi2015 ER - TY - JOUR AU - Heon, S. AU - Yeap, B. Y. AU - Britt, G. J. AU - Costa, D. B. AU - Rabin, M. S. AU - Jackman, D. M. PY - 2010 DA - 2010// TI - Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib JO - Clin Cancer Res VL - 16 ID - Heon2010 ER - TY - JOUR AU - Eichler, A. F. AU - Kahle, K. T. AU - Wang, D. L. AU - Joshi, V. A. AU - Willers, H. AU - Engelman, J. A. PY - 2010 DA - 2010// TI - EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer JO - Neuro-Oncology. VL - 12 ID - Eichler2010 ER - TY - JOUR AU - Enomoto, Y. AU - Takada, K. AU - Hagiwara, E. AU - Kojima, E. PY - 2013 DA - 2013// TI - Distinct features of distant metastasis and lymph node stage in lung adenocarcinoma patients with epidermal growth factor receptor gene mutations JO - Respir Investig VL - 51 ID - Enomoto2013 ER - TY - JOUR AU - Gerosa, M. AU - Nicolato, A. AU - Foroni, R. AU - Tomazzoli, L. AU - Bricolo, A. PY - 2005 DA - 2005// TI - Analysis of long-term outcomes and prognostic factors in patients with non-small cell lung cancer brain metastases treated by gamma knife radiosurgery JO - J Neurosurg VL - 102 ID - Gerosa2005 ER - TY - JOUR AU - Zindler, J. D. AU - Rodrigues, G. AU - Haasbeek, C. J. AU - Haan, P. F. AU - Meijer, O. W. AU - Slotman, B. J. PY - 2013 DA - 2013// TI - The clinical utility of prognostic scoring systems in patients with brain metastases treated with radiosurgery JO - Radiother Oncol VL - 106 ID - Zindler2013 ER - TY - JOUR AU - Rades, D. AU - Schild, S. E. AU - Lohynska, R. AU - Veninga, T. AU - Stalpers, L. J. AU - Dunst, J. PY - 2007 DA - 2007// TI - Two radiation regimens and prognostic factors for brain metastases in nonsmall cell lung cancer patients JO - Cancer. VL - 110 ID - Rades2007 ER - TY - JOUR AU - Sperduto, P. W. AU - Berkey, B. AU - Gaspar, L. E. AU - Mehta, M. AU - Curran, W. PY - 2008 DA - 2008// TI - A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database JO - Int J Radiat Oncol Biol Phys VL - 70 ID - Sperduto2008 ER - TY - JOUR AU - Rotin, D. L. AU - Paklina, O. V. AU - Kobiakov, G. L. AU - Shishkina, L. V. AU - Kravchenko, E. V. AU - Stepanian, M. A. PY - 2013 DA - 2013// TI - Lung cancer metastases to the brain: clinical and morphological prognostic factors JO - Zh Vopr Neirokhir Im N N Burdenko VL - 77 ID - Rotin2013 ER - TY - JOUR AU - Gong, X. AU - Zhou, D. AU - Liang, S. AU - Zhou, C. PY - 2016 DA - 2016// TI - Analyses of prognostic factors in cases of non-small cell lung cancer with multiple brain metastases JO - Onco Targets Ther VL - 9 ID - Gong2016 ER - TY - JOUR AU - Yang, J. J. AU - Zhou, Q. AU - Yan, H. H. AU - Zhang, X. C. AU - Chen, H. J. AU - Tu, H. Y. PY - 2017 DA - 2017// TI - A phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations JO - Br J Cancer VL - 116 ID - Yang2017 ER - TY - JOUR AU - Shi, Y. AU - Zhang, L. AU - Liu, X. AU - Zhou, C. AU - Zhang, L. AU - Zhang, S. PY - 2013 DA - 2013// TI - Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial JO - Lancet Oncol VL - 14 ID - Shi2013 ER - TY - JOUR AU - Urata, Y. AU - Katakami, N. AU - Morita, S. AU - Kaji, R. AU - Yoshioka, H. AU - Seto, T. PY - 2016 DA - 2016// TI - Randomized phase III study comparing Gefitinib with Erlotinib in patients with previously treated advanced lung adenocarcinoma: WJOG 5108L JO - J Clin Oncol VL - 34 ID - Urata2016 ER - TY - JOUR AU - Zimmermann, S. AU - Dziadziuszko, R. AU - Peters, S. PY - 2014 DA - 2014// TI - Indications and limitations of chemotherapy and targeted agents in non-small cell lung cancer brain metastases JO - Cancer Treat Rev VL - 40 ID - Zimmermann2014 ER - TY - JOUR AU - Diener-West, M. AU - Dobbins, T. W. AU - Phillips, T. L. AU - Nelson, D. F. PY - 1989 DA - 1989// TI - Identification of an optimal subgroup for treatment evaluation of patients with brain metastases using RTOG study 7916 JO - Int J Radiat Oncol Biol Phys VL - 16 ID - Diener-West1989 ER - TY - JOUR AU - Borgelt, B. AU - Gelber, R. AU - Kramer, S. AU - Brady, L. W. AU - Chang, C. H. AU - Davis, L. W. PY - 1980 DA - 1980// TI - The palliation of brain metastases: final results of the first two studies by the radiation therapy oncology group JO - Int J Radiat Oncol Biol Phys VL - 6 ID - Borgelt1980 ER - TY - JOUR AU - Jamal-Hanjani, M. AU - Spicer, J. PY - 2012 DA - 2012// TI - Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of epidermal growth factor receptor-mutant non-small cell lung cancer metastatic to the brain JO - Clin Cancer Res VL - 18 ID - Jamal-Hanjani2012 ER - TY - JOUR AU - Park, S. J. AU - Kim, H. T. AU - Lee, D. H. AU - Kim, K. P. AU - Kim, S. W. AU - Suh, C. PY - 2012 DA - 2012// TI - Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation JO - Lung Cancer VL - 77 ID - Park2012 ER - TY - JOUR AU - Iuchi, T. AU - Shingyoji, M. AU - Sakaida, T. AU - Hatano, K. AU - Nagano, O. AU - Itakura, M. PY - 2013 DA - 2013// TI - Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma JO - Lung Cancer VL - 82 ID - Iuchi2013 ER - TY - JOUR AU - Omuro, A. M. AU - Kris, M. G. AU - Miller, V. A. AU - Franceschi, E. AU - Shah, N. AU - Milton, D. T. PY - 2005 DA - 2005// TI - High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib JO - Cancer. VL - 103 ID - Omuro2005 ER - TY - JOUR AU - Magnuson, W. J. AU - Yeung, J. T. AU - Guillod, P. D. AU - Gettinger, S. N. AU - Yu, J. B. AU - Chiang, V. L. PY - 2016 DA - 2016// TI - Impact of deferring radiation therapy in patients with epidermal growth factor receptor-mutant non-small cell lung Cancer who develop brain metastases JO - Int J Radiat Oncol Biol Phys VL - 95 ID - Magnuson2016 ER - TY - JOUR AU - Weber, B. AU - Winterdahl, M. AU - Memon, A. AU - Sorensen, B. S. AU - Keiding, S. AU - Sorensen, L. PY - 2011 DA - 2011// TI - Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor JO - J Thorac Oncol VL - 6 ID - Weber2011 ER - TY - JOUR AU - Ballard, P. AU - Yates, J. W. AU - Yang, Z. AU - Kim, D. W. AU - Yang, J. C. AU - Cantarini, M. PY - 2016 DA - 2016// TI - Preclinical comparison of Osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity JO - Clin Cancer Res VL - 22 ID - Ballard2016 ER - TY - STD TI - Vishwanathan K, Varrone A, Varnas K. Abstract CT013: Osimertinib displays high brain exposure in healthy subjects with intact blood-brain barrier: a microdose positron emission tomography (PET) study with 11C-labelled osimertinib. Cancer Res:7482018. ID - ref38 ER - TY - JOUR AU - Mok, T. S. AU - Wu, Y. L. AU - Ahn, M. J. AU - Garassino, M. C. AU - Kim, H. R. AU - Ramalingam, S. S. PY - 2017 DA - 2017// TI - Osimertinib or platinum-Pemetrexed in EGFR T790M-positive lung Cancer JO - N Engl J Med VL - 376 ID - Mok2017 ER - TY - JOUR AU - Metro, G. AU - Provencio, M. AU - Kim, D. W. PY - 2019 DA - 2019// TI - 1521P - Osimertinib in epidermal growth factor receptor (EGFR) T790M advanced non-small cell lung cancer (NSCLC): analysis of patients with central nervous system (CNS) metastases in a real-world study (ASTRIS) JO - Ann Oncol VL - 30 ID - Metro2019 ER - TY - JOUR AU - Wang, C. AU - Lu, X. AU - Lyu, Z. AU - Bi, N. AU - Wang, L. PY - 2018 DA - 2018// TI - Comparison of up-front radiotherapy and TKI with TKI alone for NSCLC with brain metastases and EGFR mutation: a meta-analysis JO - Lung Cancer VL - 122 ID - Wang2018 ER - TY - JOUR AU - Chen, Y. AU - Wei, J. AU - Cai, J. AU - Liu, A. PY - 2019 DA - 2019// TI - Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis JO - BMC Cancer VL - 19 ID - Chen2019 ER - TY - JOUR AU - Dong, K. AU - Liang, W. AU - Zhao, S. AU - Guo, M. AU - He, Q. AU - Li, C. PY - 2019 DA - 2019// TI - EGFR-TKI plus brain radiotherapy versus EGFR-TKI alone in the management of EGFR-mutated NSCLC patients with brain metastases JO - Transl Lung Cancer Res VL - 8 ID - Dong2019 ER - TY - JOUR AU - Zhuang, H. Q. AU - Sun, J. AU - Yuan, Z. Y. AU - Wang, J. AU - Zhao, L. J. AU - Wang, P. PY - 2009 DA - 2009// TI - Radiosensitizing effects of gefitinib at different administration times in vitro JO - Cancer Sci VL - 100 ID - Zhuang2009 ER - TY - JOUR AU - Halatsch, M. E. AU - Low, S. AU - Mursch, K. AU - Hielscher, T. AU - Schmidt, U. AU - Unterberg, A. PY - 2009 DA - 2009// TI - Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation JO - J Neurosurg VL - 111 ID - Halatsch2009 ER - TY - JOUR AU - Zhuang, H. AU - Wang, J. AU - Zhao, L. AU - Yuan, Z. AU - Wang, P. PY - 2013 DA - 2013// TI - The theoretical foundation and research progress for WBRT combined with erlotinib for the treatment of multiple brain metastases in patients with lung adenocarcinoma JO - Int J Cancer VL - 133 ID - Zhuang2013 ER - TY - JOUR AU - Zeng, Y. D. AU - Zhang, L. AU - Liao, H. AU - Liang, Y. AU - Xu, F. AU - Liu, J. L. PY - 2012 DA - 2012// TI - Gefitinib alone or with concomitant whole brain radiotherapy for patients with brain metastasis from non-small-cell lung cancer: a retrospective study JO - Asian Pac J Cancer Prev VL - 13 ID - Zeng2012 ER - TY - JOUR AU - Cai, L. AU - Zhu, J. F. AU - Zhang, X. W. AU - Lin, S. X. AU - Su, X. D. AU - Lin, P. PY - 2014 DA - 2014// TI - A comparative analysis of EGFR mutation status in association with the efficacy of TKI in combination with WBRT/SRS/surgery plus chemotherapy in brain metastasis from non-small cell lung cancer JO - J Neuro-Oncol VL - 120 ID - Cai2014 ER - TY - JOUR AU - Welsh, J. W. AU - Komaki, R. AU - Amini, A. AU - Munsell, M. F. AU - Unger, W. AU - Allen, P. K. PY - 2013 DA - 2013// TI - Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer JO - J Clin Oncol VL - 31 ID - Welsh2013 ER - TY - JOUR AU - Hasegawa, Y. AU - Ando, M. AU - Maemondo, M. AU - Yamamoto, S. AU - Isa, S. AU - Saka, H. PY - 2015 DA - 2015// TI - The role of smoking status on the progression-free survival of non-small cell lung cancer patients harboring activating epidermal growth factor receptor (EGFR) mutations receiving first-line EGFR tyrosine kinase inhibitor versus platinum doublet chemotherapy: a meta-analysis of prospective randomized trials JO - Oncologist. VL - 20 ID - Hasegawa2015 ER - TY - JOUR AU - D'Angelo, S. P. AU - Pietanza, M. C. AU - Johnson, M. L. AU - Riely, G. J. AU - Miller, V. A. AU - Sima, C. S. PY - 2011 DA - 2011// TI - Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas JO - J Clin Oncol VL - 29 ID - D'Angelo2011 ER - TY - JOUR AU - Peduzzi, P. AU - Concato, J. AU - Kemper, E. AU - Holford, T. R. AU - Feinstein, A. R. PY - 1996 DA - 1996// TI - A simulation study of the number of events per variable in logistic regression analysis JO - J Clin Epidemiol VL - 49 ID - Peduzzi1996 ER -