Table 3 Univariate and multivariate analyses of overall survival and disease-free survival of OSCC patients by Cox regression analysis
From: Tumor expression of miR-448 is a prognostic marker in oral squamous cell carcinoma
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | CI (95%) | P value | HR | CI (95%) | P value | |
OS | ||||||
MiR-448 expression (Low/High) | 3.422 | 1.944-5.782 | 0.002 | 4.456 | 2.215-6.892 | 0.004 |
Gender (Female/Male) | 1.352 | 0.563-1.723 | NS | - | - | - |
Age (<60 / ≥60 years) | 1.532 | 0.744-2.631 | NS | - | - | - |
Smoking status (No/Yes) | 1.318 | 0.633-1.428 | NS | - | - | - |
Tumor site (Tongue/Non-tongue) | 0.932 | 0.782-1.345 | NS | - | - | - |
Grade (Well-moderate/Poor) | 1.784 | 0.742-2.342 | NS | - | - | - |
T stage (T1-T2/T3-T4) | 2.933 | 1.428-5.236 | 0.011 | 2.671 | 1.763-6.213 | 0.016 |
Lymph node metastasis (No/Yes) | 3.782 | 1.922-7.678 | 0.004 | 4.523 | 2.456-8.892 | 0.007 |
TNM stage (I–II/III–IV) | 3.213 | 1.457-5.231 | 0.008 | 4.231 | 1.774-6.732 | 0.012 |
DFS | ||||||
MiR-448 expression (Low/High) | 3.622 | 1.782-6.773 | 0.001 | 4.923 | 2.672-8.723 | 0.002 |
Gender (Female/Male) | 1.523 | 0.731-1.953 | NS | - | - | - |
Age (<60 / ≥60 years) | 1.786 | 0.892-2.993 | NS | - | - | - |
Smoking status (No/Yes) | 1.554 | 0.458-1.889 | NS | - | - | - |
Tumor site (Tongue/Non-tongue) | 0.782 | 0.336-1.231 | NS | - | - | - |
Grade (Well-moderate/Poor) | 1.993 | 0.823-2.562 | NS | - | - | - |
T stage (T1-T2/T3-T4) | 2.532 | 1.632-5.773 | 0.008 | 2.892 | 1.933-6.663 | 0.011 |
Lymph node metastasis (No/Yes) | 3.922 | 2.213-8.442 | 0.003 | 4.872 | 2.773-9.032 | 0.005 |
TNM stage (I–II/III–IV) | 3.552 | 1.642-5.833 | 0.006 | 4.521 | 1.883-6.521 | 0.009 |