Fig. 5

Silencing of USP18 inhibited tumorigenicity of human cervical cancer cells in vivo. a & b the tumor volume and weight in nude mice injected with Caski cells transfected with siNC and siUSP18. *** p < 0.001 vs siNC. N = 5 for each group. c TUNEL staining assay was performed to examine the apoptosis of siNC and siUSP18 tumours. *** p < 0.001 vs siNC. Three replications were analysed for each analysis. d Western blot was used to examine the protein levels of USP18, p-AKT, AKT, β-catenin in siNC and siUSP18 tumours. *** p < 0.001 vs siNC. Three replications were analysed for each analysis. The full-length gels are presented in Supplementary Figure 5D