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Fig. 3 | BMC Cancer

Fig. 3

From: USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway

Fig. 3

USP18 silencing suppressed the proliferation and induced apoptosis in human cervical cancer cells. a & b siUSP18–1 or siUSP18–2 significantly suppressed the proliferation of Caski and SiHa cells, n = 3 for each group. * p < 0.05 vs siNC; *** p < 0.001 vs siNC. c The apoptosis of Caski and SiHa cells were upregulated after transfecting with siUSP18–1 or siUSP18–2, n = 3 for each group. *** p < 0.001 vs siNC. d & e Western blot was used to examine the protein contents of Ki-67, Cyclin D1, cleaved PARP, BAX and β-catenin in Caski and SiHa cells that transfected with siUSP18–1 or siUSP18–2 respectively, n = 3 for each group. *** p < 0.001 vs siNC. The full-length gels are presented in Supplementary Figure 3D-E. f & g Western blot was used to examine the protein contents of USP18, Cleaved caspase-3, AKT and p-AKT in Caski and SiHa cells that transfected with siUSP18–1 or siUSP18–2 respectively, n = 3 for each group. *** p < 0.001 vs siNC. The full-length gels are presented in Supplementary Figure 3F-G

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