Parameters | Reference case | Minimal value | Maximal value | Distribution | References |
---|---|---|---|---|---|
Genetic alterations | |||||
 Prevalence EGFR | 0.28 | 0.22 | 0.34 | Beta | |
 Prevalence Alk | 0.05 | 0.02 | 0.07 | Beta | |
 Prevalence Ros1 | 0.02 | 0.01 | 0.03 | Beta | |
Test accuracy | |||||
 Sensitivity EGFR | 0.98 | 0.95 | 0.99 | Beta | |
 Specificity EGFR | 0.89 | 0.69 | 1.00 | Beta | |
 Sensitivity Alk | 1.00 | 0.75 | 1.00 | Beta | [34] |
 Specificity Alk | 1.00 | 1.00 | 1.00 | Beta | [34] |
 Sensitivity Ros1 | 1.00 | 0.75 | 1.00 | Beta | Assumption, as reference test |
 Specificity Ros1 | 1.00 | 1.00 | 1.00 | Beta | Assumption, as reference test |
 Sensitivity NGS | 0.99 | 0.96 | 1.00 | Beta | |
 Specificity NGS | 1.00 | 0.82 | 1.00 | Beta | |
Test performance | |||||
 pUnknow EGFR | 0.13 | 0.06 | 0.34 | Beta | |
 pUnknow FISH (ALK e ROS) | 0.10 | 0.02 | 0.38 | Beta | |
 pUnknow NGS | 0.04 | 0.00 | 0.09 | Beta | |
Test costs | |||||
 cEGFR | 428.14 | 363.57 | 477.39 | Gama | AMB, CBHPM - 2016; ANS,D-TISS; search from current Brazilian market price |
 cFISH Alk | 573.70 | 423.11 | 753.77 | Gama | |
 cFISH Ros1 | 564.99 | 423.11 | 753.77 | Gama | |
 cNGS | 1874.37 | 1502.51 | 2110.55 | Gama | |
Drug price | |||||
 Cisplatin 50 mg | 113.57 | 63.11 | 141.95 | Gama | Anvisa, Câmara de Regulação do Mercado de Medicamentos - CMED |
 Crizotinib 250 mg | 15,084.79 | 11,245.02 | 19,298.94 | Gama | |
 Docetaxel 80 mg | 1271.57 | 1463.21 | 1589.47 | Gama | |
 Gefitinib 250 mg | 2256.31 | 1631.86 | 2820.38 | Gama | |
 Gencitabin 1000 mg | 1881.43 | 799.77 | 2351.78 | Gama | |
 Pemetrexed 500 mg | 3418.88 | 2484.86 | 4273.60 | Gama | |
Utilities | |||||
 1st line with Gefitinib (M1) | 0.65 | 0.60 | 0.71 | Beta | |
 1st line with Crizotinib (M2) | 0.66 | 0.60 | 0.71 | Beta | |
 Pemetrexed + cisplatin (M3, 1st Progression in M1 & M2) | 0.62 | 0.56 | 0.67 | Beta | |
 2nd or 3rd line with standard chemotherapy (2nd Progression in M1, M2, M3 and 1st Progression in M3) | 0.57 | 0.51 | 0.64 | Beta | |
Others | |||||
Discount rate | 0.05 | 0.00 | 0.10 | Beta | [27] |