Skip to main content

Table 1 Study flowchart of clinical study

From: Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study

Study procedures Inclusion Neo-adjuvant Chemotherapy Surgery Adjuvant Chemotherapy Follow up  
week < 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Check in- and exclusion x                      
Sign Informed Consent x                      
Blood withdrawal for ctDNA + plasma x a        x b     x c          x d  
CT-scan x        x f               
Surgery          xg              
CAPOX   C1D1    C2D1         C3D1 e    C4D 1       
Record medical history x x    x         x    x       
Document concomitant medication/therapies x x    x         x    x       
  1. a: blood withdrawal may be done at screening or immediately before cycle 1 day 1
  2. b: blood withdrawal to be performed after cycle 2 week 3 and before surgery
  3. c: blood withdrawal to be performed before cycle 3 day 1
  4. d: blood withdrawal to be performed approximately 12 weeks after surgery
  5. e: Cycle 3 day 1 should ideally start within 4–8 weeks after surgery, at the latest: 12 weeks after surgery
  6. f: CT should be performed after completion of cycle 2 and before surgery
  7. g: Surgery should ideally be performed 7–9 weeks after Cycle 1 day 1, but has to be performed 11 weeks after Cycle 1 day 1