Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study

Table 1 Study flowchart of clinical study

Study procedures	Inclusion	Neo-adjuvant Chemotherapy							Surgery				Adjuvant Chemotherapy						Follow up
week	< 0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21
Check in- and exclusion	x
Sign Informed Consent	x
Blood withdrawal for ctDNA + plasma	x ^a							x ^b				x ^c									x ^d
CT-scan	x							x ^f
Surgery									x^g
CAPOX		C1D1			C2D1								C3D1 ^e			C4D 1
Record medical history	x	x			x								x			x
Document concomitant medication/therapies	x	x			x								x			x

^a: blood withdrawal may be done at screening or immediately before cycle 1 day 1
^b: blood withdrawal to be performed after cycle 2 week 3 and before surgery
^c: blood withdrawal to be performed before cycle 3 day 1
^d: blood withdrawal to be performed approximately 12 weeks after surgery
^e: Cycle 3 day 1 should ideally start within 4–8 weeks after surgery, at the latest: 12 weeks after surgery
^f: CT should be performed after completion of cycle 2 and before surgery
^g: Surgery should ideally be performed 7–9 weeks after Cycle 1 day 1, but has to be performed 11 weeks after Cycle 1 day 1

ISSN: 1471-2407