The presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in advanced hypopharyngeal squamous cell carcinoma

Table 4 Multivariate analyses of OS, DFS, DMFS and LRFS in the entire population (N = 132)

Variable	OS			DFS			DMFS			LRFS
Variable	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P
Site (Not PS vs PS)	1.621	0.706–3.726	0.255	1.756	0.810–3.807	0.154	1.549	0.614–3.909	0.354	2.590	1.034–6.491	0.042*
Stage (IVA/IVB vs III)				1.496	0.563–3.979	0.419	2.489	0.530–11.688	0.248
T category (T4a vs T1–3)	1.880	0.947–3.735	0.071	2.196	1.077–4.476	0.030*	2.115	0.911–4.911	0.081
CD8 (Low vs High)	1.231	0.509–2.977	0.644	0.716	0.300–1.709	0.452	0.698	0.217–2.242	0.546
Foxp3 (Low vs High)	2.387	0.932–6.111	0.070	2.066	0.885–4.826	0.094	3.253	1.038–10.196	0.043*
CD8/Foxp3 (Low vs High)				2.613	1.203–5.673	0.015*	3.606	1.334–9.748	0.011*
CD8/CD4 (Low vs High)				1.708	0.871–3.349	0.119				2.418	1.043–5.606	0.040*

Multivariate cox regression analyses were performed for all variables that were significantly associated with survival in univariate analysis
Abbreviations: PS Pyriform sinus, OS Overall survival, DFS Disease-free survival, DMFS distant metastasis-free survival, LRFS Local relapse-free survival, G1 Well differentiated, G2 Moderately differentiated, G3 poorly differentiated
*The P value is significant

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