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Table 3 Univariate analyses of OS, DFS, DMFS and LRFS in the entire population (N = 132)

From: The presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in advanced hypopharyngeal squamous cell carcinoma

Variable

OS

DFS

DMFS

LRFS

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

HR

95%CI

P

Age, years (≥60y vs <60y)

0.521

0.254–1.073

0.077

0.637

0.341–1.188

0.156

0.787

0.361–1.715

0.547

0.594

0.263–1.346

0.212

Smoke (Yes vs No)

0.596

0.259–1.372

0.224

0.738

0.328–1.662

0.463

0.611

0.230–1.621

0.322

1.753

0.413–7.438

0.446

Drink history (Yes vs No)

0.748

0.348–1.607

0.457

0.945

0.452–1.976

0.881

0.822

0.330–2.050

0.675

1.991

0.596–6.653

0.263

Site (Not PS vs PS)

2.534

1.144–5.610

0.022*

2.524

1.206–5.284

0.014*

2.629

1.054–6.556

0.038*

2.600

1.038–6.513

0.041*

Grade (G3 vs G2 + G1)

0.689

0.285–1.665

0.408

1.033

0.508–2.102

0.929

1.283

0.539–3.053

0.573

1.586

0.684–3.675

0.282

Stage (IVA/IVB vs III)

1.785

0.739–4.313

0.198

2.457

1.035–5.834

0.042*

0.208

0.049–0.880

0.033*

2.848

0.852–9.518

0.089

T category (T4a vs T1–3)

2.259

1.151–4.436

0.018*

2.508

1.365–4.610

0.003*

2.681

1.231–5.842

0.013*

2.069

0.944–4.538

0.070

N category (N2–3 vs N0–1)

1.319

0.652–2.666

0.441

1.682

0.874–3.236

0.120

1.681

0.731–3.868

0.222

2.361

0.943–5.915

0.067

Laryngectomy (Total vs Partial)

1.896

0.853–4.215

0.117

1.860

0.951–3.638

0.070

2.233

0.894–5.578

0.085

2.370

0.946–5.938

0.066

CD8 (Low vs High)

2.324

1.127–4.795

0.022*

1.892

1.005–3.560

0.048*

2.391

1.038–5.505

0.040*

0.900

0.411–1.974

0.793

CD4 (Low vs High)

1.174

0.593–2.323

0.645

1.119

0.610–2.052

0.717

1.656

0.749–3.661

0.212

0.968

0.442–2.123

0.936

Foxp3 (Low vs High)

3.253

1.511–7.001

0.003*

1.999

1.063–3.760

0.032*

3.006

1.263–7.153

0.013*

1.615

0.726–3.596

0.240

CD8/Foxp3 (Low vs High)

1.490

0.752–2.953

0.253

2.205

1.159–4.195

0.016*

2.463

1.069–5.674

0.034*

1.522

0.683–3.391

0.305

CD8/CD4 (Low vs High)

1.857

0.930–3.705

0.079

2.058

1.099–3.851

0.024*

1.947

0.878–4.317

0.101

2.424

1.046–5.621

0.039*

  1. Abbreviations: PS Pyriform sinus, OS Overall survival, DFS Disease-free survival, DMFS Distant metastasis-free survival, LRFS Local relapse-free survival, G1 Well differentiated, G2 Moderately differentiated, G3 Poorly differentiated
  2. *The P value is significant
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BMC Cancer

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