Table 2 Stratiedanalysis of the relationship between hypothyroidism and breast cancer risk
From: Does hypothyroidism increase the risk of breast cancer: evidence from a meta-analysis
Variable | No.of studies | OR(95%CI) | P | Heterogeneity | Model used | |
|---|---|---|---|---|---|---|
I2 | Ph | |||||
Region | ||||||
Europe | 12 | 0.93 (0.88–0.99) | < 0.001 | 0 | 0.877 | Fixed |
North America | 5 | 0.86 (0.60–1.11) | < 0.001 | 93.8% | 0 | Randomed |
Asia | 2 | 1.17 (0.98–1.35) | < 0.001 | 0 | 0.319 | Fixed |
Study design | ||||||
Case-control | 13 | 0.85 (0.62–1.09) | < 0.001 | 80.4% | 0 | Randomed |
Cohort | 6 | 0.96 (0.91–1.01) | < 0.001 | 0 | 0.517 | Fixed |
Follow-up date | ||||||
> 4 | 7 | 0.96 (0.91–1.00) | < 0.001 | 0 | 0.435 | Fixed |
≤ 4 | 9 | 0.80 (0.54–1.07) | < 0.001 | 81.0% | 0 | Randomed |