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Table 8 Cox proportional hazard regression analysis for the overall survival and cancer-specific survival of lung HGNEC patients with SPM

From: Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)

Variable overall survival cancer-specific survival
HR 95% CI P HR 95% CI P
Age
  < 65 year   Reference    Reference  
  ≥ 65 year 1.242 1.085–1.422 0.002 0.981 0.827–1.163 0.824
Sex
 Male   Reference    Reference  
 Female 0.962 0.843–1.098 0.569 0.897 0.760–1.059 0.198
Race
 White   Reference    Reference  
 Black 0.922 0.727–1.169 0.503 0.870 0.642–1.177 0.366
 Other 1.011 0.712–1.434 0.953 1.137 0.747–1.731 0.550
Stage
 Localized   Reference    Reference  
 Regional 1.608 1.317–1.964 0.000 1.783 1.373–2.314 0.000
 Distant 2.113 1.716–2.602 0.000 2.370 1.809–3.103 0.000
 Unknown/unstaged 1.230 0.835–1.811 0.295 1.120 0.661–1.898 0.674
Radiation
 None/Unknown   Reference    Reference  
 Beam radiation 1.997 1.233–3.237 0.005 2.254 1.299–3.909 0.004
 Other radiation 0.991 0.833–1.178 0.914 0.950 0.763–1.182 0.643
Chemotherapy
 Yes   Reference    Reference  
 None/Unknown 0.881 0.715–1.085 0.232 0.915 0.704–1.190 0.509
Latency
  ≥ 60 months   Reference    Reference  
 6–59 months 3.862 3.310–4.507 0.000 3.761 3.093–4.573 0.000