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Table 5 Risk of SPM after lung HGNEC, stratified by age

From: Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)

 

Observed

Expected

O/E

95% CI

Excess risk

< 50 years

All Sites

31

8.26

3.75

2.55–5.33

87.27

All Solid Tumours

28

7.44

3.76

2.5–5.44

78.9

Oral cavity and pharynx

2

0.25

8.07

0.98–29.16

6.72

 Floor of Mouth

1

0.01

81.76

2.07–455.51

3.79

 Gum and Other Mouth

1

0.02

40.99

1.04–228.4

3.74

Digestive System

8

1.2

6.66

2.88–13.12

26.09

 Colon, Rectum and Anus

3

0.72

4.14

0.85–12.1

8.73

 Pancreas

5

0.12

41.88

13.6–97.74

18.73

Respiratory System

7

0.56

12.41

4.99–25.58

24.7

 Lung and Bronchus

7

0.49

14.22

5.72–29.3

24.97

Miscellaneous

2

0.09

21.21

2.57–76.62

7.31

50–64 years

All Sites

394

214.04

1.84

1.66–2.03

82.14

All Solid Tumours

361

194.61

1.86

1.67–2.06

75.95

Oral cavity and pharynx

13

6.26

2.08

1.11–3.55

3.08

 Floor of Mouth

3

0.37

8.13

1.68–23.76

1.2

 Pharynx

4

0.92

4.35

1.18–11.13

1.41

 Oropharynx

4

0.27

14.73

4.01–37.71

1.7

Digestive System

62

36.56

1.7

1.3–2.17

11.61

 Esophagus

7

2.14

3.27

1.31–6.73

2.22

 Small Intestine

4

1.04

3.83

1.04–9.81

1.35

 Ascending Colon

6

1.93

3.11

1.14–6.77

1.86

 Pancreas

17

4.97

3.42

1.99–5.48

5.49

Respiratory System

186

27.27

6.82

5.88–7.88

72.45

 Lung and Bronchus

180

24.94

7.22

6.2–8.35

70.77

Male Genital System

15

36.56

0.41

0.23–0.68

−9.84

 Prostate

14

36.09

0.39

0.21–0.65

−10.08

Urinary System

32

14.84

2.16

1.47–3.04

7.83

 Urinary Bladder

15

6.92

2.17

1.21–3.57

3.69

 Kidney

17

7.4

2.3

1.34–3.68

4.38

All Lymphatic and Hematopoietic Diseases

28

15.75

1.78

1.18–2.57

5.59

 Leukemia

24

4.52

5.32

3.41–7.91

8.89

 Acute Lymphocytic Leukemia

3

0.24

12.48

2.57–36.48

1.26

 Non-Lymphocytic Leukemia

18

2.08

8.67

5.14–13.7

7.27

 Acute Non-Lymphocytic Leukemia

16

1.36

11.75

6.72–19.08

6.68

 Myeloid and Monocytic Leukemia

18

1.94

9.29

5.51–14.68

7.33

 Acute Myeloid Leukemia

14

1.23

11.4

6.23–19.13

5.83

 Acute Monocytic Leukemia

2

0.08

24.43

2.96–88.23

0.88

> 65 years

All Sites

936

665.19

1.41

1.32–1.5

83.43

All Solid Tumours

852

588.37

1.45

1.35–1.55

81.22

Oral cavity and pharynx

15

13.55

1.11

0.62–1.83

0.45

 Floor of Mouth

4

0.73

5.48

1.49–14.04

1.01

Digestive System

157

127.41

1.23

1.05–1.44

9.12

 Colon, Rectum and Anus

97

67.29

1.44

1.17–1.76

9.15

 Colon and Rectum

91

65.22

1.4

1.12–1.71

7.94

 Colon excluding Rectum

77

49.1

1.57

1.24–1.96

8.6

 Ascending Colon

22

10.23

2.15

1.35–3.25

3.62

Respiratory System

457

117.15

3.9

3.55–4.28

104.7

 Lung and Bronchus

440

111.17

3.96

3.6–4.35

101.3

Breast

49

82.13

0.6

0.44–0.79

−10.21

Female Genital System

10

30.69

0.33

0.16–0.6

−6.37

 Corpus and Uterus, NOS

2

17.05

0.12

0.01–0.42

−4.64

Male Genital System

44

107.8

0.41

0.3–0.55

−19.65

 Prostate

43

106.87

0.4

0.29–0.54

−19.68

Urinary System

83

60.72

1.37

1.09–1.69

6.86

All Lymphatic and Hematopoietic Diseases

66

59.42

1.11

0.86–1.41

2.03

 Leukemia

42

18.82

2.23

1.61–3.02

7.14

 Non-Lymphocytic Leukemia

37

9.31

3.97

2.8–5.48

8.53

 Acute Non-Lymphocytic Leukemia

34

6.31

5.39

3.73–7.53

8.53

 Myeloid and Monocytic Leukemia

37

8.44

4.39

3.09–6.04

8.8

 Acute Myeloid Leukemia

32

5.66

5.65

3.87–7.98

8.11