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Table 4 Risk of SPM after lung HGNEC, stratified by race

From: Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)

 

Observed

Expected

O/E

95% CI

Excess risk

White

All Sites

1187

782.04

1.52

1.43–1.61

81.89

All Solid Tumours

1080

695.27

1.55

1.46–1.65

77.8

Oral Cavity and Pharynx

26

17.87

1.45

0.95–2.13

1.64

 Floor of Mouth

8

0.99

8.11

3.5–15.98

1.42

 Oropharynx

4

0.68

5.9

1.61–15.09

0.67

Digestive System

195

140.5

1.39

1.20–1.60

11.02

 Splenic Flexure

5

1.6

3.13

1.02–7.30

0.69

 Pancreas

40

22.39

1.79

1.28–2.43

3.56

Respiratory System

568

127.47

4.46

4.10–4.84

89.08

Breast

78

110.42

0.71

0.56–0.88

−6.56

Female Genital System

17

42.44

0.4

0.23–0.64

−5.14

Male Genital System

46

120.8

0.38

0.28–0.51

−15.13

Urinary System

102

68.89

1.48

1.21–1.80

6.7

 Urinary Bladder

62

41.77

1.48

1.14–1.90

4.09

 Kidney

36

23.49

1.53

1.07–2.12

2.53

All Lymphatic and Hematopoietic Diseases

84

67.83

1.24

0.99–1.53

3.27

 Leukemia

59

21.46

2.75

2.09–3.55

7.59

Black

All Sites

122

78.39

1.56

1.29–1.86

85.42

All Solid Tumours

114

70.91

1.61

1.33–1.93

84.42

Oral Cavity and Pharynx

2

1.55

1.29

0.16–4.67

0.89

 Gum and Other Mouth

2

0.22

9.1

1.1–32.89

3.49

Digestive System

27

16.98

1.59

1.05–2.31

19.62

 Esophagus

4

0.89

4.5

1.23–11.52

6.09

Respiratory System

54

13.17

4.1

3.08–5.35

79.97

Male Genital System

10

18.97

0.53

0.25–0.97

−17.58

Kidney

7

2.74

2.55

1.03–5.26

8.34

Adrenal Gland

1

0.02

41.01

1.04–228.51

1.91

Leukemia

4

1.48

2.7

0.73–6.91

4.93

Other (American Indian/AK Native, Asian/Pacific Islander)

  

All Sites

52

26.33

1.97

1.47–2.59

108.64

All Solid Tumours

47

23.6

1.99

1.46–2.65

99.04

 Oral Cavity and Pharynx

2

0.62

3.24

0.39–11.7

5.85

 Pharynx

2

0.19

10.47

1.27–37.81

7.66

 Oropharynx

1

0.01

69.8

1.77–388.92

4.17

Digestive System

5

7.56

0.66

0.21–1.54

−10.82

Respiratory System

28

4.23

6.63

4.4–9.58

100.62

Leukemia

3

0.56

5.4

1.11–15.77

10.34