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Table 3 Standardized incidence ratio (SIR) analysis of SMP in patients with a history of an initial primary lung HGNEC by sex, race, age and year of diagnosis, SEER-18

From: Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)

  Observed Expected O/E 95% CI Excess risk
Total 1361 887.49 1.53 1.45–1.62 83.11
Age and Sex
Male
 All Men 619 469.98 1.32 1.22–1.43 59.83
  < 50 15 2.88 5.21 2.92–8.60 100.27
 50–64 187 106.35 1.76 1.52–2.03 83.72
  > 65 417 360.75 1.16 1.05–1.27 39.99
Female
 All Women 742 417.5 1.78 1.65–1.91 101.19
  < 50 16 5.38 2.98 1.70–4.83 76.02
 50–64 207 107.69 1.92 1.67–2.20 80.9
  > 65 519 304.43 1.7 1.56–1.86 116.64
Sex and Race
Male
 White 524 404.86 1.29 1.19–1.41 56.6
 Black 61 46.61 1.31 1.00–1.68 60.13
 Other 34 18.03 1.89 1.31–2.64 111.65
Female
 White 663 377.18 1.76 1.63–1.90 100.63
 Black 61 31.78 1.92 1.47–2.47 107.75
 Other 18 8.31 2.17 1.28–3.42 104.01
Sex and Year
Male
 2000–2004 57 85.79 0.66 0.50–0.86 −66.4
 2005–2010 230 184.25 1.25 1.09–1.42 47.7
 2011–2016 332 199.94 1.66 1.49–1.85 120.29
Female
 2000–2004 63 62.86 1 0.77–1.28 0.3
 2005–2010 239 157.77 1.51 1.33–1.72 66.49
 2011–2016 440 196.87 2.23 2.03–2.45 162.62