Fig. 1
X-tile analysis of survival data of 67 included patients. Every pixel of the plot represents the χ2 log-rank value generated from corresponding division of the data. Direct associations between DPLT and survival (higher DPLT indicates a better outcome) are colored green, whereas indirect associations (higher DPLT indicates poorer outcome) are colored red. A brighter (green or red) pixel color represents a larger χ2 log-rank value and a stronger association. a. Determination of the optimal cut-point. Survival data used for cut-point optimization is PFS. The optimal cut-point (DPLT = 212 × 109/L) appears at the brightest pixel (The black dot on the straight line below). b. A histogram showing the distribution of the entire cohort and the established cut-point. c. Kaplan-Meier curve of PFS between high and low DPLT groups. The cutoff value is DPLT = 212 × 109/L. A significantly better PFS is observed in high DPLT group (p-value given by cross-validation is 0.016. The blue line represents for low DPLT group while the gray line represents for high DPLT group) d. Kaplan-Meier curve of OS between high and low DPLT groups. The cutoff value is DPLT = 212 × 109/L. A better OS is observed in high DPLT group, but without significance (p value given by cross validation is 0.106. The blue line represents for low DPLT group and the gray line represents for high DPLT group)