Table 3 Immunoexpression of the several putative prognostic markers and associations with major clinicopathological variables
Clinicopathological variables | MIB-1 ≤ 50% | MIB-1 > 50% | p-value |
Relapse (% within relapse) | |||
No | 12/42 (28.6) | 30/42 (71.4) | 0.028a |
Yes | 2/28 (7.1) | 26/28 (92.9) | |
Histology (% within histology) | |||
Seminoma | 4/28 (14.3) | 24/28 (85.7) | 0.329 |
Non-seminoma | 10/42 (23.8) | 32/42 (76.2) | |
Vascular invasion (% within vascular invasion) | |||
No | 11/44 (25.0) | 33/44 (75.0) | 0.197 |
Yes | 3/25 (12.0) | 22/25 (88.0) | |
Clinicopathological variables | TEX19 negative | TEX19 positive | p-value |
Relapse (% within relapse) | |||
No | 34/42 (81.0) | 8/42 (19.0) | 0.552 |
Yes | 21/28 (75.0) | 7/28 (25.0) | |
Histology (% within histology) | |||
Seminoma | 27/28 (96.4) | 1/28 (3.6) | 0.003a |
Non-seminoma | 28/42 (66.7) | 14/42 (33.3) | |
Vascular invasion (% within vascular invasion) | |||
No | 32/44 (72.7) | 12/44 (27.3) | 0.139 |
Yes | 22/25 (88.0) | 3/25 (12.0) | |
Clinicopathological variables | CXCL12 negative (tumor cells) | CXCL12 positive (tumor cells) | p-value |
Relapse (% within relapse) | |||
No | 27/42 (64.3) | 15/42 (35.7) | 0.533 |
Yes | 20/28 (71.4) | 8/28 (28.6) | |
Histology (% within histology) | |||
Seminoma | 27/28 (96.2) | 1/28 (3.6) | < 0.001a |
Non-seminoma | 20/42 (47.6) | 22/42 (52.4) | |
Vascular invasion (% within vascular invasion) | |||
No | 30/44 (68.2) | 14/44 (31.8) | 0.723 |
Yes | 16/25 (64.0) | 9/25 (36.0) | |
Clinicopathological variables | CXCR4 weak/moderate | CXCR4 strong | p-value |
Relapse (% within relapse) | |||
No | 8/42 (19.0) | 34/42 (81.0) | 0.506 |
Yes | 3/28 (10.7) | 25/28 (89.3) | |
Histology (% within histology) | |||
Seminoma | 8/28 (28.6) | 20/28 (71.4) | 0.021a |
Non-seminoma | 3/42 (7.1) | 39/42 (92.9) | |
Vascular invasion (% within vascular invasion) | |||
No | 8/44 (18.2) | 36/44 (81.8) | 0.734 |
Yes | 3/25 (12.0) | 22/25 (88.0) | |
Clinicopathological variables | CXCR4 nuclear exclusive | CXCR4 non-nuclear exclusive | p-value |
Relapse (% within relapse) | |||
No | 22/42 (52.4) | 20/42 (47.6) | 0.049a |
Yes | 8/28 (28.6) | 20/28 (71.4) | |
Histology (% within histology) | |||
Seminoma | 21/28 (75.0) | 7/28 (25.0) | < 0.001a |
Non-seminoma | 9/42 (21.4) | 33/42 (78.6) | |
Vascular invasion (% within vascular invasion) | |||
No | 26/44 (59.1) | 18/44 (40.9) | < 0.001a |
Yes | 3/25 (12.0) | 22/25 (88.0) | |
Clinicopathological variables | Beta catenin score ≤ 100 | Beta catenin score > 100 | p-value |
Relapse (% within relapse) | |||
No | 11/42 (26.2) | 31/42 (73.8) | 0.045a |
Yes | 2/28 (7.1) | 26/28 (92.9) | |
Histology (% within histology) | |||
Seminoma | 11/28 (39.3) | 17/28 (60.7) | < 0.001a |
Non-seminoma | 2/42 (4.8) | 40/42 (95.2) | |
Vascular invasion (% within vascular invasion) | |||
No | 8/44 (18.2) | 36/44 (81.8) | 1.0 |
Yes | 4/25 (16.0) | 21/25 (84.0) | |