Fig. 4

High circulating level of endothelin-1 and big endothelin-1 in patients with breast cancer with relative left ventricular hypertrophy. a Quantification of endothelin-1 (ET-1) levels in both breast cancer patients (n = 28) and a control cohort of women with comparable baseline factors (n = 17). b Correlation between ET-1 concentration and indexed left ventricular (LV) mass, c Correlation between ET-1 concentration and indexed left ventricular end systolic volume (LVESV), d Correlation between ET-1 concentration and indexed left ventricular end diastolic volume (LVEDV), e Correlation between ET-1 concentration and left ventricular ejection fraction (LVEF) in breast cancer patients (n = 28). f Quantification of big ET-1 levels in in both breast cancer patients (n = 28) and the control cohort (n = 17). g Correlation between big ET-1 concentration and indexed LV mass, h Correlation between big ET-1 concentration and indexed LVESV, i Correlation between big ET-1 concentration and indexed LVEDV, j Correlation between big ET-1 concentration and LVEF in breast cancer patients (n = 28). Dots represent individual values. Results are shown as means ± SD. Comparisons between two groups were made by unpaired t-test. * p < 0.05 vs healthy control. The correlations between ET-1 or Big ET-1 levels and LV parameters was determined using Pearson’s correlation coefficient