Fig. 1
From: The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice models
Schematic diagram of creation of the SP-C/p53-273H transgenic mouse. A 1.8-kb human mutant p53-273H cDNA (arginine to histidine substitution at codon 273) was placed under the transcriptional control of a 3.7-kb region of the human SP-C promoter. Transgenic mice were generated by microinjection of a total of 6.7-kb XhoI fragment of the SP-C/p53-273H construct into the pro-nuclei of FVB/N mouse zygotes by standard methods