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Fig. 4 | BMC Cancer

Fig. 4

From: Multiple formin proteins participate in glioblastoma migration

Fig. 4

Immunohistochemistry for FHOD1 and INF2 in TP53 mutant glioblastoma, comparing solid areas with infiltrating areas. The top micrographs show p53 staining in solid tumour (left) and area of diffuse infiltration (right). Tumour cells have positive staining nuclei, while non-neoplastic cells remain negative. FHOD1 staining in the corresponding tumour areas show negative staining in a vast majority of tumour cells and positive staining in tumour vessel walls. The infiltrating area of the same glioblastoma shows moderate/high FHOD1 expression in 20% of infiltrating tumour cells. The lower micrographs show INF2 staining in the same glioblastoma. The solid tumour is virtually INF2 negative, except for tumour vessels (lower left). The infiltrating area of the same tumour shows moderate/high expression in 20% of tumour cells (lower right). Insets show details with higher magnification

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