Skip to main content

Table 5 Baseline features of lesion status in the gastric mucosa of patients with AG and without Helicobacter pylori infection stratified by MTHFR C677T genotype

From: Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study

  Genotypes C allele dominance
CC
n = 31
CT
n = 69
TT
n = 28
P CC + CT
n = 100
TT
n = 28
P
Lesions in biopsies
 Incisura
  yes 10 (32%) 30 (43%) 18 (64%) 0.04 40 (40%) 18 (64%) 0.02
  no 21 (68%) 39 (57%) 10 (36%)   60 (60%) 10 (36%)  
 Antrum
  yes 28 (90%) 62 (90%) 21 (75%) 0.15 90 (90%) 21 (75%) 0.06
  no 3 (10%) 7 (10%) 7 (25%)   10 (10%) 7 (25%)  
 Corpus
  yes 1 (3%) 5 (7%) 5 (18%) 0.17 6 (6%) 5 (18%) 0.22
  no 30 (97%) 64 (93%) 23 (82%)   94 (94%) 23 (82%)  
Atrophy
  Absent/Mild 19 (61%) 43 (62%) 12 (43%) 0.19 62 (62%) 12 (43%) 0.07
  Moderate/Severe 12 (39%) 26 (38%) 16 (57%)   38 (38%) 16 (57%)  
IM
  Absent/Mild 14 (45%) 34 (49%) 6 (21%) 0.04 48 (48%) 6 (21%) 0.01
  Moderate/Severe 17 (55%) 35 (51%) 22 (79%)   52 (52%) 22 (79%)  
Moderate-to-severe lesions
  Absent/Mild 11 (35%) 28 (41%) 4 (14%) 0.04 39 (39%) 4 (14%) 0.01
  Moderate/Severe 20 (65%) 41 (59%) 24 (86%)   61 (61%) 24 (86%)  
OLGA
  I-II 26 (84%) 60 (87%) 17 (61%) 0.119 86 (86%) 17 (61%) 0.003
  III-IV 5 (16%) 9 (13%) 11 (39%)   14 (17%) 11 (39%)  
OLGIM
  I-II 20 (65%) 48 (70%) 13 (46%) 0.162 68 (68%) 13 (46%) 0.036
  III-IV 11 (35%) 21 (30%) 15 (54%)   32 (32%) 15 (54%)  
  1. Lesions included atrophy or intestinal metaplasia; atrophy: atrophy located in any one biopsy; intestinal metaplasia: intestinal metaplasia located in any one biopsy; moderate-to-severe lesions: moderate to severe intestinal metaplasia, moderate to severe atrophy or low-grade intraepithelial neoplasia in any one location; CI: confidence interval