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Table 5 Baseline features of lesion status in the gastric mucosa of patients with AG and without Helicobacter pylori infection stratified by MTHFR C677T genotype

From: Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection: a case control study

 

Genotypes

C allele dominance

CC

n = 31

CT

n = 69

TT

n = 28

P

CC + CT

n = 100

TT

n = 28

P

Lesions in biopsies

 Incisura

  yes

10 (32%)

30 (43%)

18 (64%)

0.04

40 (40%)

18 (64%)

0.02

  no

21 (68%)

39 (57%)

10 (36%)

 

60 (60%)

10 (36%)

 

 Antrum

  yes

28 (90%)

62 (90%)

21 (75%)

0.15

90 (90%)

21 (75%)

0.06

  no

3 (10%)

7 (10%)

7 (25%)

 

10 (10%)

7 (25%)

 

 Corpus

  yes

1 (3%)

5 (7%)

5 (18%)

0.17

6 (6%)

5 (18%)

0.22

  no

30 (97%)

64 (93%)

23 (82%)

 

94 (94%)

23 (82%)

 

Atrophy

  Absent/Mild

19 (61%)

43 (62%)

12 (43%)

0.19

62 (62%)

12 (43%)

0.07

  Moderate/Severe

12 (39%)

26 (38%)

16 (57%)

 

38 (38%)

16 (57%)

 

IM

  Absent/Mild

14 (45%)

34 (49%)

6 (21%)

0.04

48 (48%)

6 (21%)

0.01

  Moderate/Severe

17 (55%)

35 (51%)

22 (79%)

 

52 (52%)

22 (79%)

 

Moderate-to-severe lesions

  Absent/Mild

11 (35%)

28 (41%)

4 (14%)

0.04

39 (39%)

4 (14%)

0.01

  Moderate/Severe

20 (65%)

41 (59%)

24 (86%)

 

61 (61%)

24 (86%)

 

OLGA

  I-II

26 (84%)

60 (87%)

17 (61%)

0.119

86 (86%)

17 (61%)

0.003

  III-IV

5 (16%)

9 (13%)

11 (39%)

 

14 (17%)

11 (39%)

 

OLGIM

  I-II

20 (65%)

48 (70%)

13 (46%)

0.162

68 (68%)

13 (46%)

0.036

  III-IV

11 (35%)

21 (30%)

15 (54%)

 

32 (32%)

15 (54%)

 
  1. Lesions included atrophy or intestinal metaplasia; atrophy: atrophy located in any one biopsy; intestinal metaplasia: intestinal metaplasia located in any one biopsy; moderate-to-severe lesions: moderate to severe intestinal metaplasia, moderate to severe atrophy or low-grade intraepithelial neoplasia in any one location; CI: confidence interval