Table 1 Helicobacter pylori-negative patients characteristics stratified by MTHFR C677T genotypes

Age (years), mean ± SD

55 ± 10

56 ± 9

54 ± 13

N.S

 27–44

5

5

7

 45–62

17

48

14

 63–80

9

16

7

Male, n (%)

15 (48.4%)

34 (49.3%)

15 (53.6%)

N.S

Family history of gastric cancer in first-degree relatives, n (%)

7 (22.6%)

19 (27.5%)

4 (14.3%)

N.S

Smoking status

N.S

 Never

23

50

19

 Current/Former

8

19

9

Alcohol status

N.S

 Never

23

53

19

 Current/Former

8

16

9

Gastrin-17 (pmol/L)

8.2 ± 20.6

5.8 ± 11.4

3.8 ± 6.6

N.S

Pepsinogen I (μg/L)

104.8 ± 54.8

103.6 ± 69.5

81.1 ± 31.3

N.S

Pepsinogen II (μg/L)

10.5 ± 6.3

10.1 ± 8.6

8.4 ± 3.8

N.S

PGR

11.3 ± 4.7

11.4 ± 4.0

10.5 ± 3.4

N.S

BMI (kg/m²)

22.4 ± 2.8

22.3 ± 2.8

22.6 ± 2.5

N.S