Fig. 1
Overview of the genetic features in 342 cases. a Frequency of genetic alterations that distinguish the GCB and non-GCB subtypes of 342 cases, sorted by log10P value for the difference between the two subgroups. b The correlation among different types of MYD88 and CD79B mutations. c Circos plot depicting the correlation among different types of CD79B mutations (Y196 missense, truncating, and non-Y196 missense mutations). d Positions and types of somatic mutations encoded in CCND3 (NP_001751.1) and CD79B (NP_000617.1). e The sequence of CD79B (chr:62007140–62,006,802, GRCh37/hg19). The black arrow denotes the splice acceptor site mutation c.550-1G > A (NM_000626.4). The red arrow denotes two exposed potential splice acceptor sites. Coding sequences are highlighted by black frames. f Genetic alterations that are most related to the MYC-trans signature, BCL2-trans signature, BCL6-trans signature, and MC signature. Recurrent altered genes in GCB and non-GCB cases without our set of genetic signatures were also shown. g Venn diagrams describing the difference between cases exhibited initially defined signatures, and cases exhibited extended genetic signatures obtained from a convergence predicted by an iterative random forest algorithm