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Table 1 Details of supervised and home-based exercise prescription for participants on a 3-week chemotherapy cycle protocol

From: Study protocol of the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial: a two-arm, two-centre randomized controlled trial

Cycle Week Supervised Program Home-based Program
   Freq. Duration
(minutes)
Intensity
(% HRR)
Freq. Duration
(minutes)
Intensity (RPE)
1 1 3 20–25 50–55a, 55–60 0 0 0
2 3 30 55–60 0 0 0
3 3 25–30 60–65 1 15–20 12–13
2 4 3 30–35 50–55a, 60–65 1 15–20 12–13
5 3 25–35 60–65, VT 1 15–20 12–13
6 3 25–35 60–65, VT 1 20–30 12–13
3 7 3 35–40 55–60a, 60–65 1 20–30 12–13
8 3 25–35 65–70, VT 1 20–30 12–13
9 3 25–35 65–70, VT 1 20–30 12–13
4 10 3 35–40 55–60a, 65–70 1 20–30 12–13
11 3 20–35 65–70, HIIT 1 20–30 12–13
12 3 20–40 65–70, HIIT 1 20–30 12–13
5 13 3 40 55–60a, 65–70 1 20–30 12–13
14 3 20–35 70–75, VT/HIITb 1 20–30 12–13
15 3 20–35 70–75, VT/HIITb 1 20–30 12–13
6 16 3 40 55–60a, 65–70 1 20–30 12–13
17 3 20–35 70–75, VT/HIITb 1 20–30 12–13
18 3 20–35 70–75, VT/HIITb 1 20–30 12–13
7 19 3 40 55–60a, 65–70 1 20–30 12–13
20 3 20–35 70–75, VT/HIITb 1 20–30 12–13
21 3 20–35 70–75, VT/HIITb 1 20–30 12–13
8 22 3 40 55–60a, 65–70 1 20–30 12–13
23 3 20–35 70–75, VT/HIITb 1 20–30 12–13
24 3 20–35 70–75, VT/HIITb 1 20–30 12–13
  1. Freq. Frequency, HIIT high-intensity interval training session (10–16 bouts of 30 s at 100% peak workload and 1–2 min of active recovery), HRR Heart rate reserve, RPE Rating of perceived exertion, VT ventilatory threshold session (4 bouts of 5 min at VT and 3 min of active recovery)
  2. aThe first exercise session immediately after chemotherapy infusion is prescribed at 50–55% HRR (first two cycles) and 50–60% HRR (remaining cycles) (i.e., 5–10% reduction in workload). bAfter Cycle 5, VT and HIIT sessions are prescribed based on participants' preference. Participants perform a 5-min warm-up before and 5-min cool-down after each exercise session