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Table 2 Multivariate Analysis on the Associations of DNA Methylation Marker, MRS and Risk of CRC of Nested Case Control Study Based on EPIC-Italy Cohort

From: A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility

CpG ID

Gene Name

Entire Dataset

Training Dataset

Testing Dataset

OR

95% CI

P-value

OR

95% CI

P-value

OR

95% CI

P-value

cg06551493

PTPN12

0.62

0.49, 0.78

6.58e-05

0.71

0.54, 0.91

0.009

0.42

0.25, 0.68

7.18e-04

cg01419670

NA

2.12

1.62, 2.85

1.47e-07

2.36

1.71, 3.36

6.16e-07

1.62

1.00, 2.82

0.06

cg16530981

NA

1.96

1.52, 2.57

5.01e-07

2.15

1.60, 2.98

1.29e-06

1.53

0.99, 2.57

0.08

cg18022036

NA

0.56

0.45, 0.70

5.47e-07

0.54

0.41, 0.69

3.97e-06

0.67

0.43, 1.03

0.07

cg12691488

NA

0.73

0.47, 1.10

0.14

0.67

0.40, 1.08

0.11

0.84

0.34, 1.95

0.70

cg17292758

PPFIA3

0.79

0.64, 0.98

0.04

0.79

0.61, 1.02

0.07

0.79

0.51, 1.20

0.27

cg16170495

RNF39

0.66

0.54, 0.80

3.17e-05

0.68

0.54, 0.85

0.001

0.62

0.41, 0.90

0.01

cg11240062

NA

1.25

1.00, 1.57

0.06

1.30

1.00, 1.69

0.05

1.11

0.70, 1.78

0.67

cg21585512

LOC399959

0.68

0.55, 0.83

1.61e-04

0.58

0.45, 0.74

1.64e-05

0.94

0.64, 1.38

0.75

cg24702253

MRGPRG

1.74

1.28, 2.58

0.002

1.78

1.24, 2.81

0.005

0.74

1.01, 4.58

0.11

cg17187762

NA

0.76

0.63, 0.93

0.006

0.78

0.62, 0.97

0.03

0.66

0.44, 0.98

0.04

cg05983326

PCDHGA1

0.69

0.57, 0.84

2.68e-04

0.73

0.57, 0.91

0.007

0.57

0.38, 0.84

0.006

cg06825163

LGR6

0.70

0.57, 0.86

5.47e-04

0.67

0.52, 0.84

8.11e-04

0.82

0.56, 1.21

0.34

cg11885357

ESYT3

0.89

0.73, 1.08

0.23

0.83

0.65, 1.04

0.11

1.07

0.72, 1.59

0.74

cg08829299

ATHL1

0.86

0.70, 1.04

0.13

0.84

0.66, 1.05

0.13

0.93

0.63, 1.37

0.69

cg07044115

NA

0.77

0.63, 0.93

0.008

0.82

0.66, 1.03

0.07

0.60

0.40, 0.89

0.01

  1. Abbreviations: CI Confidence interval, CRC Colorectal cancer, MRS Methylation risk score, ORs Adjusted for age and gender, P values < 0.05 are in bold