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Table 2 Multivariate Analysis on the Associations of DNA Methylation Marker, MRS and Risk of CRC of Nested Case Control Study Based on EPIC-Italy Cohort

From: A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility

CpG ID Gene Name Entire Dataset Training Dataset Testing Dataset
OR 95% CI P-value OR 95% CI P-value OR 95% CI P-value
cg06551493 PTPN12 0.62 0.49, 0.78 6.58e-05 0.71 0.54, 0.91 0.009 0.42 0.25, 0.68 7.18e-04
cg01419670 NA 2.12 1.62, 2.85 1.47e-07 2.36 1.71, 3.36 6.16e-07 1.62 1.00, 2.82 0.06
cg16530981 NA 1.96 1.52, 2.57 5.01e-07 2.15 1.60, 2.98 1.29e-06 1.53 0.99, 2.57 0.08
cg18022036 NA 0.56 0.45, 0.70 5.47e-07 0.54 0.41, 0.69 3.97e-06 0.67 0.43, 1.03 0.07
cg12691488 NA 0.73 0.47, 1.10 0.14 0.67 0.40, 1.08 0.11 0.84 0.34, 1.95 0.70
cg17292758 PPFIA3 0.79 0.64, 0.98 0.04 0.79 0.61, 1.02 0.07 0.79 0.51, 1.20 0.27
cg16170495 RNF39 0.66 0.54, 0.80 3.17e-05 0.68 0.54, 0.85 0.001 0.62 0.41, 0.90 0.01
cg11240062 NA 1.25 1.00, 1.57 0.06 1.30 1.00, 1.69 0.05 1.11 0.70, 1.78 0.67
cg21585512 LOC399959 0.68 0.55, 0.83 1.61e-04 0.58 0.45, 0.74 1.64e-05 0.94 0.64, 1.38 0.75
cg24702253 MRGPRG 1.74 1.28, 2.58 0.002 1.78 1.24, 2.81 0.005 0.74 1.01, 4.58 0.11
cg17187762 NA 0.76 0.63, 0.93 0.006 0.78 0.62, 0.97 0.03 0.66 0.44, 0.98 0.04
cg05983326 PCDHGA1 0.69 0.57, 0.84 2.68e-04 0.73 0.57, 0.91 0.007 0.57 0.38, 0.84 0.006
cg06825163 LGR6 0.70 0.57, 0.86 5.47e-04 0.67 0.52, 0.84 8.11e-04 0.82 0.56, 1.21 0.34
cg11885357 ESYT3 0.89 0.73, 1.08 0.23 0.83 0.65, 1.04 0.11 1.07 0.72, 1.59 0.74
cg08829299 ATHL1 0.86 0.70, 1.04 0.13 0.84 0.66, 1.05 0.13 0.93 0.63, 1.37 0.69
cg07044115 NA 0.77 0.63, 0.93 0.008 0.82 0.66, 1.03 0.07 0.60 0.40, 0.89 0.01
  1. Abbreviations: CI Confidence interval, CRC Colorectal cancer, MRS Methylation risk score, ORs Adjusted for age and gender, P values < 0.05 are in bold