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Table 4 Risk factors for OS in CC patients with stage IB-IIA by univariate and multiple Cox regression analysis

From: Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

Variables Univariate Multivariate
HR(95% CI) p value HR(95% CI) p value
Age (high vs low) 1.74 (0.88–3.51) 0.113   
BMI (high vs low) 1.11 (0.56–2.14) 0.751   
Diabetes (yes vs no) 1.08 (0.58–2.02) 0.765   
Hypertension (yes vs no) 1.15 (0.61–2.11) 0.651   
Hyperlipemia (yes vs no) 1.43 (0.62–3.22) 0.357   
Pathological type (SCC vs non-SCC) 1.89 (0.92–4.11) 0.079   
FIGO stage (IIA vs IB) 2.91 (1.32–6.14) 0.008* 2.72 (1.18–5.01) 0.022*
Tumor grade (G2/3 vs G1) 0.98 (0.50–1.87) 0.914   
Tumor size (≥4 cm vs < 4 cm) 1.41 (0.56–3.31) 0.431   
Adjuvant therapy (yes vs no) 1.59 (0.93–2.68) 0.087   
LVSI (yes vs no) 2.53 (1.20–5.61) 0.016* 1.48 (0.81–2.69) 0.211
LNM (yes vs no) 1.84 (0.67–4.79) 0.211   
Depth of invasion(≥2/3 vs < 2/3) 1.41 (1.07–1.87) 0.018* 1.22 (0.83–1.77) 0.281
Vaginal invasion (yes vs no) 1.33 (0.96–1.78) 0.081   
Hemoglobin (high vs low) 0.70 (0.40–1.24) 0.265   
Platelet (high vs low) 1.55 (0.97–2.47) 0.061   
WBC (high vs low) 1.44 (0.95–2.11) 0.068   
Total cholesterol (high vs low) 1.26 (0.65–2.33) 0.443   
CRP (high vs low) 1.25 (0.84–1.81) 0.194   
FAR (> 7.75 vs ≤7.75) 2.78 (1.56–5.06) 0.003* 2.83 (1.41–5.35) 0.008*
  1. Abbreviations: CC cervical cancer, BMI body mass index, SCC squamous cell carcinoma, FIGO International Federation of Gynecology and Obstetrics, FAR fibrinogen-to-albumin ratio, LVSI lympho-vascular space invasion, LNM lymphatic node metastasis, WBC white blood cell, CRP C-reactive protein, HR hazard ratio, CI confidence interval
  2. * P < 0.05