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Table 3 Risk factors for RFS in CC patients with stage IB-IIA by univariate and multiple Cox regression analysis

From: Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

Variables Univariate Multivariate
HR(95% CI) p value HR(95% CI) p value
Age (high vs low) 1.47 (0.97–2.21) 0.076   
BMI (high vs low) 0.99 (0.67–1.48) 0.923   
Diabetes (yes vs no) 1.21 (0.82–1.77) 0.358   
Hypertension (yes vs no) 1.03 (0.63–1.65) 0.892   
Hyperlipemia (yes vs no) 1.11 (0.72–1.61) 0.628   
Pathological type (SCC vs non-SCC) 1.21 (0.30–4.93) 0.783   
FIGO stage (IIA vs IB) 2.33 (1.29–4.24) 0.009* 2.11 (1.14–3.79) 0.017*
Tumor grade (G2/3 vs G1) 1.16 (0.68–2.06) 0.553   
Tumor size (≥4 cm vs < 4 cm) 1.83 (1.26–4.27) 0.026* 1.57 (0.88–2.81) 0.136
Adjuvant therapy (yes vs no) 1.61 (0.47–5.11) 0.413   
LVSI (yes vs no) 1.09 (0.69–1.69) 0.676   
LNM (yes vs no) 1.59 (1.04–2.49) 0.029* 1.84 (1.12–2.88) 0.032*
Depth of invasion(≥2/3 vs < 2/3) 1.16 (0.46–2.92) 0.718   
Vaginal invasion (yes vs no) 1.24 (0.70–2.21) 0.411   
Hemoglobin (high vs low) 0.74 (0.31–1.79) 0.521   
Platelet (high vs low) 1.11 (0.60–2.04) 0.712   
WBC (high vs low) 1.66 (0.52–5.22) 0.388   
Total cholesterol (high vs low) 1.14 (0.73–1.82) 0.554   
CRP (high vs low) 1.32 (0.49–3.14) 0.533   
FAR (> 7.75 vs ≤7.75) 2.53 (1.24–5.18) 0.009* 2.41 (1.36–4.11) 0.011*
  1. Abbreviations: CC cervical cancer, BMI body mass index, SCC squamous cell carcinoma, FIGO International Federation of Gynecology and Obstetrics, FAR fibrinogen-to-albumin ratio, LVSI lympho-vascular space invasion, LNM lymphatic node metastasis, WBC white blood cell, CRP C-reactive protein, HR hazard ratio, CI confidence interval
  2. * P < 0.05