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Table 1 Clinicopathological variables associated with FAR in CC patients with stage IB-IIA

From: Preoperative fibrinogen-to-albumin ratio, a potential prognostic factor for patients with stage IB-IIA cervical cancer

Parameters Total FAR≤7.75 FAR> 7.75 p value
Number 278 180 98
Age (years) 45.5 ± 6.3 44.8 ± 6.7 46.8 ± 6.4 0.016*
BMI (kg/m2) 22.3 ± 2.0 22.3 ± 2.1 22.4 ± 1.8 0.691
Comorbidities (n, %)    
 Diabetes 31 (11.2) 20 (11.1) 11 (11.2) 0.977
 Hypertension 39 (14.0) 22 (12.2) 17 (17.3) 0.240
 Hyperlipemia 26 (9.4) 17 (9.4) 9 (9.2) 0.943
Pathological type   0.297
 SCC 248 (89.2) 158 (87.7) 90 (91.8)
 Non-SCC 30 (10.8) 22 (12.3) 8 (8.2)
FIGO stage   0.033*
 IB 146 (50.4) 103 (57.2) 43 (43.9)
 IIA 132 (47.5) 77 (42.8) 55 (56.1)
Tumor grade (n, %)   0.590
 G1 53 (19.1) 36 (20.0) 17 (17.3)
 G2 166 (59.7) 109 (60.6) 57 (58.2)
 G3 59 (21.2) 35 (19.4) 24 (24.5)
Maximum tumor size   0.447
  ≥ 4 cm 99 (35.6) 67 (37.2) 32 (32.7)
  < 4 cm 179 (64.4) 113 (62.8) 66 (67.3)
Adjuvant therapy     0.748
 No 54 (19.4) 42 (23.3) 12 (12.2)
 Chemoradiotherapy 77 (27.7) 45 (25.0) 32 (32.7)
 Chemotherapy 108 (38.8) 67 (37.2) 41 (41.8)
 Radiotherapy 39 (10.8) 26 (14.4) 13 (7.2)
LVSI   0.409
 No 247 (88.8) 162 (90.0) 85 (86.7)
 Yes 31 (11.2) 18 (10.0) 13 (13.3)
LNM     0.547
 No 232 (83.5) 152 (84.4) 80 (81.6)
 Yes 46 (16.5) 28 (15.6) 18 (18.4)
Depth of invasion   0.022*
  ≥ 2/3 100 (36.0) 56 (31.1) 44 (44.9)
  < 2/3 178 (64.0) 124 (68.9) 54 (55.1)
Vaginal invasion   0.738
 No 260 (93.5) 169 (93.9) 91 (92.9)
 Yes 18 (6.5) 11 (6.1) 7 (7.1)
  1. Abbreviations: CC cervical cancer, BMI body mass index, SCC squamous cell carcinoma, FIGO International Federation of Gynecology and Obstetrics, FAR fibrinogen-to-albumin ratio, LVSI lympho-vascular space invasion, LNM lymphatic node metastasis
  2. P-values were calculated by Student’s t test, Mann–Whitney U test or Chi-squared test
  3. * P < 0.05