Table 1 Clinicopathological variables associated with FAR in CC patients with stage IB-IIA

Number

278

180

98

–

Age (years)

45.5 ± 6.3

44.8 ± 6.7

46.8 ± 6.4

0.016*

BMI (kg/m²)

22.3 ± 2.0

22.3 ± 2.1

22.4 ± 1.8

0.691

Comorbidities (n, %)

–

 Diabetes

31 (11.2)

20 (11.1)

11 (11.2)

0.977

 Hypertension

39 (14.0)

22 (12.2)

17 (17.3)

0.240

 Hyperlipemia

26 (9.4)

17 (9.4)

9 (9.2)

0.943

Pathological type

–

–

0.297

 SCC

248 (89.2)

158 (87.7)

90 (91.8)

–

 Non-SCC

30 (10.8)

22 (12.3)

8 (8.2)

–

FIGO stage

–

–

0.033*

 IB

146 (50.4)

103 (57.2)

43 (43.9)

–

 IIA

132 (47.5)

77 (42.8)

55 (56.1)

–

Tumor grade (n, %)

–

–

0.590

 G1

53 (19.1)

36 (20.0)

17 (17.3)

–

 G2

166 (59.7)

109 (60.6)

57 (58.2)

–

 G3

59 (21.2)

35 (19.4)

24 (24.5)

–

Maximum tumor size

–

–

0.447

  ≥ 4 cm

99 (35.6)

67 (37.2)

32 (32.7)

–

  < 4 cm

179 (64.4)

113 (62.8)

66 (67.3)

–

Adjuvant therapy

0.748

 No

54 (19.4)

42 (23.3)

12 (12.2)

–

 Chemoradiotherapy

77 (27.7)

45 (25.0)

32 (32.7)

–

 Chemotherapy

108 (38.8)

67 (37.2)

41 (41.8)

–

 Radiotherapy

39 (10.8)

26 (14.4)

13 (7.2)

–

LVSI

–

–

0.409

 No

247 (88.8)

162 (90.0)

85 (86.7)

–

 Yes

31 (11.2)

18 (10.0)

13 (13.3)

–

LNM

0.547

 No

232 (83.5)

152 (84.4)

80 (81.6)

–

 Yes

46 (16.5)

28 (15.6)

18 (18.4)

–

Depth of invasion

–

–

0.022*

  ≥ 2/3

100 (36.0)

56 (31.1)

44 (44.9)

–

  < 2/3

178 (64.0)

124 (68.9)

54 (55.1)

–

Vaginal invasion

–

–

0.738

 No

260 (93.5)

169 (93.9)

91 (92.9)

–

 Yes

18 (6.5)

11 (6.1)

7 (7.1)

–