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Fig. 2 | BMC Cancer

Fig. 2

From: PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts

Fig. 2

Homologous recombination status and cell death in melanoma and healthy tissue cells. a Homologous recombination activity evaluated by DNA DSB induction and repair 24 h after exposure to DNA-PK inhibitor CC-115 and 10 Gy irradiation. Decreased remaining γH2AX foci and RAD51 foci indicates deficiency in homologous recombination. Apoptotic and necrotic rates in melanoma cells b A375M, c BIMA, d ILSA, e Mel624, f PMelL, g RERO and healthy donor skin fibroblasts h SBLF9, i SBLF7 treated w/o 50 nmol/l talazoparib, w/o 2 Gy IR or w/o 2500 nmol/l niraparib, w/o 2 Gy IR; * = p ≤ 0.05; each value represents mean ± SD (n = 3 or n = 4)

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