Table 5 Adverse events
|  | Grade1 | Grade2 | Grade3 | Grade4 | All grade | Grade ≥ 3 |
|---|---|---|---|---|---|---|
Total | 38 (83%) | 18 (39%) | 7 (15%) | – | 41 (89%) | 7 (15%) |
Hematologic | ||||||
 Neutropenia | 5 | 4 | 1 | – | 10 (22%) | 1 (2%) |
 Leukocytopenia | 7 | 6 | – | – | 13 (28%) | – |
 Anemia | 13 | 5 | 2 | – | 20 (43%) | 2 (4%) |
 Thrombocytopenia | 6 | 2 | – | – | 8 (17%) | – |
Gastrointestinal | ||||||
 Nausea | 9 | 2 | 1 | – | 13 (26%) | 1 (2%) |
 Vomiting | 2 | 0 | 1 | – | 3 (7%) | 1 (2%) |
 Anorexia | 5 | 4 | 2 | – | 11 (24%) | 2 (4%) |
 Diarrhea | 4 | 5 | 2 | – | 11 (24%) | 2 (4%) |
 Abdominal pain | – | – | 1 | – | 1 (2%) | 1 (2%) |
Others | ||||||
 Total bilirubin elevation | 4 | – | – | – | 4 (9%) | – |
 AST elevation | 2 | – | – | – | 2 (4%) | – |
 ALT elevation | 1 | – | – | – | 1 (2%) | – |
 Creatinine elevation | 1 | 1 | – | – | 2 (4%) | – |
 Aphthous stomatitis | 3 | 2 | – | – | 5 (11%) | – |
 Fatigue | 11 | 7 | – | – | 18 (39%) | – |
 Pigmentation | 11 | – | – | – | 11 (24%) | – |
 Rash | 3 | 3 | – | – | 6 (13%) | – |
 Chest pain | – | 1 | – | – | 1 (2%) | – |