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Table 2 The associations between gene methylation and risk of breast cancer and different molecular types of breast cancer

From: Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study

   Molecular
types a
No. of Unmethylation(%) No. of Methylation(%) Crude OR
(95% CI)
P
Value
ORadjustedb
(95% CI)
P
Value
ORadjustedc
(95% CI)
P
Value
WT1 Control   65(11.7) 492(88.3) 1   1   1  
  Luminal A 9(6.4) 132(93.6) 1.99(0.94-4.23) 0.07 2.61(1.18-5.74) 0.02 2.62(1.11-6.20) 0.03
  Luminal B 8(6.0) 125 (94.0) 2.12(1.50-2.99) 0.07 2.49(1.13-5.51) 0.02 3.23(1.34-7.80) 0.01
  HER-2 Enriched 5(8.9) 51(91.1) 1.34(0.51-3.50) 0.55 1.91(0.69-5.30) 0.21 1.91(0.66-5.51) 0.23
  TNBC 1(2.9) 33(27.1) 4.34(0.58-32.33) 0.15 5.63(0.73-43.63) 0.10 6.04(0.76-47.90) 0.09
All cases   26(6.5) 376(93.5) 1.92(1.18-3.13) 0.01 2.42(1.45-4.04) 0.01 3.07(1.67-5.64) <0.01
CA10 Control   209(37.5) 348(62.5) 1   1   1  
  Luminal A 40(28.4) 101(71.6) 1.52(1.00-2.26) 0.05 1.60(1.04-2.45) 0.03 1.51(0.94-2.41) 0.09
  Luminal B 34(25.6) 99(74.4) 1.79(1.17-2.74) 0.01 2.04(1.30-3.21) <0.01 1.80(1.09-2.98) 0.02
  HER-2 Enriched 18(32.1) 38(67.9) 1.27(0.71-2.29) 0.43 1.42(0.76-2.66) 0.27 1.37(0.71-2.63) 0.35
  TNBC 14(41.1) 20(58.8) 0.86(0.43-1.74) 0.67 0.94(0.45-1.96) 0.87 1.01(0.46-2.20) 0.99
All cases   119(29.6) 283(70.4) 1.43(1.08-1.88) 0.01 1.53(1.14-2.05) <0.01 1.35(0.97-1.90) 0.08
  1. aThe result excluded 38 breast cancer patients with incomplete immunohistochemical records
  2. bAdjusted for age, BMI, ethnicity, urban and rural status and family history of breast cancer and cancer
  3. cAdjusted by propensity score(potential confounder included age, BMI, urban and rural status, ethnicity, education level, mammography, gynecologic surgery, breast disease history, menstrual cycle, menopause, reproduction, abortion, breast feeding, oral contraceptive, female hormone intake, fruit intake, vegetable intake, tomato intake, broccoli intake, bean products, pungent food, pork, beef and lamb consumption, chicken consumption, sea-fish, egg, diary, fungus, pickles, alcohol consumption, tea consumption, cigarette, physical activity, occupation type, family history of breast cancer and cancer)