Neutrophil to lymphocyte ratio, not platelet to lymphocyte or lymphocyte to monocyte ratio, is predictive of patient survival after resection of early-stage pancreatic ductal adenocarcinoma

Table 3 Univariate and multivariate Cox proportional-hazard models for recurrence-free survival

Variable	Univariate Analysis HR (95% CI)	P value	Multivariable Analysis HR (95% CI)^a	P value
Gender
Female	N/A		1.0 (Reference)
Male	N/A	N/A	1.25 (0.95–1.65)	.11
Pathologic Stage
T0	N/A		1.0 (Reference)
T1	N/A	N/A	1.29 (0.55–3.00)	.56
T2	N/A	N/A	2.41 (1.21–4.80)	.01
T3	N/A	N/A	2.60 (1.27–5.29)	.009
CCI
0–3	N/A		1.0 (Reference)
4+	N/A	N/A	1.48 (1.05–2.09)	.02
NLR
< 5	1.0 (Reference)		1.0 (Reference)
≥ 5	1.65 (1.14–2.39)	.008	2.20 (1.43–3.39)	.0003
PLR
< 144.4	1.0 (Reference)		N/A
≥ 144.4	0.94 (0.73–1.22)	.64	N/A	N/A
LMR
< 2.9	1.0 (Reference)		N/A
≥ 2.9	0.90 (0.69–1.16)	.41	N/A	N/A
Perineural Invasion
No	N/A		1.0 (Reference)
Yes	N/A	N/A	1.61 (1.08–2.41)	.02
Complication Grade (3–4)^b	N/A	N/A	1.64 (1.10–2.44)	.01
Positive Nodes	N/A	N/A	1.08 (1.03–1.12)	.0003

Abbreviations: CCI Charlson Comorbidity Score, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LMR lymphocyte to monocyte ratio
^a model includes: age, gender, pathologic stage, CCI, complication score, NLR, nodal and perineural invasion status
^b Clavien-Dindo Classification of Surgical Complications

ISSN: 1471-2407