Skip to main content

Table 5 Transition of cell phenotype and related molecular mechanisms with abnormal BANCR expression in various cancers

From: High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis

Cancer type

Expression

Micro-RNAs

Targets

Functions

References

non-small

cell lung cancer

down-regulation

–

MMP2; MMP9; N-cadherin; E-cadherin

epithelial-mesenchymal transition (EMT)

[19]

hepatocellular carcinoma

up-regulation

–

Vimentin; E-Cadherin

migration, invasion

[17]

 

up-regulation

–

Bcl-2; Bax; MEK; ERK; JNK; P38;

cell invasion, proliferation and migration and apoptosis

[14]

 

up-regulation

–

 

cell proliferation and migration

[15]

 

up-regulation

–

–

cell growth, migration and invasion

[16]

osteosarcoma

up-regulation

–

ZEB1

apoptosis

[11]

papillary thyroid cancer

down-regulation

–

AKT; MEK; ERK; JNK; P38;

proliferation, migration and invasiveness

[24]

 

down-regulation

–

MAPK; PI3K-AKT

cell growth, cycle and apoptosis

[25, 26]

 

up-regulation

–

Raf; MEK; ERK;

cell autophagy

[27]

colorectal

cancer

up-regulation

–

Vimentin; E-Cadherin; MEK; ERK;

epithelial-mesenchymal transition (EMT)

[34]

 

up-regulation

miR-203

CSE1L

proliferation and invasion; cell sensitivity to adriamycin (ADR)

[42]

bladder cancer

down-regulation

–

–

apoptosis and migration

[30]

Malignant Melanoma

up-regulation

 

AKT; MEK; ERK; JNK; P38;

cell proliferation and migration

[31]

breast cancer

up-regulation

–

Bcl-2; Bax; PARP; Cleaved-caspase3

cell proliferation and invasion

[33]

 

up-regulation

–

Vimentin; E-Cadherin; MMP2; MMP9; MMP14

cell migration and invasion

[32]

clear cell renal cell

carcinoma

up-regulation

–

caspase3; caspase9; CDK4; CDK6

cell growth, cycle and apoptosis

[18]

  1. Note: BRAF-activated noncoding RNA; MMP2, The matrix metalloproteinases 2; MMP9, The matrix metalloproteinases 9; MMP14: The matrix metalloproteinases 14; PARP: poly ADP-ribose polymerase; EMT, Epithelial-Mesenchymal Transition; ZEB1, zinc finger E-box binding homeobox 1; MAPK: Mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: Jun N-terminal kinases; CDK4: cyclin-dependent kinase 4; CDK6: cyclin-dependent kinase 6; NA, Not Available