Skip to main content

Table 5 Transition of cell phenotype and related molecular mechanisms with abnormal BANCR expression in various cancers

From: High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis

Cancer type Expression Micro-RNAs Targets Functions References
non-small
cell lung cancer
down-regulation MMP2; MMP9; N-cadherin; E-cadherin epithelial-mesenchymal transition (EMT) [19]
hepatocellular carcinoma up-regulation Vimentin; E-Cadherin migration, invasion [17]
  up-regulation Bcl-2; Bax; MEK; ERK; JNK; P38; cell invasion, proliferation and migration and apoptosis [14]
  up-regulation   cell proliferation and migration [15]
  up-regulation cell growth, migration and invasion [16]
osteosarcoma up-regulation ZEB1 apoptosis [11]
papillary thyroid cancer down-regulation AKT; MEK; ERK; JNK; P38; proliferation, migration and invasiveness [24]
  down-regulation MAPK; PI3K-AKT cell growth, cycle and apoptosis [25, 26]
  up-regulation Raf; MEK; ERK; cell autophagy [27]
colorectal
cancer
up-regulation Vimentin; E-Cadherin; MEK; ERK; epithelial-mesenchymal transition (EMT) [34]
  up-regulation miR-203 CSE1L proliferation and invasion; cell sensitivity to adriamycin (ADR) [42]
bladder cancer down-regulation apoptosis and migration [30]
Malignant Melanoma up-regulation   AKT; MEK; ERK; JNK; P38; cell proliferation and migration [31]
breast cancer up-regulation Bcl-2; Bax; PARP; Cleaved-caspase3 cell proliferation and invasion [33]
  up-regulation Vimentin; E-Cadherin; MMP2; MMP9; MMP14 cell migration and invasion [32]
clear cell renal cell
carcinoma
up-regulation caspase3; caspase9; CDK4; CDK6 cell growth, cycle and apoptosis [18]
  1. Note: BRAF-activated noncoding RNA; MMP2, The matrix metalloproteinases 2; MMP9, The matrix metalloproteinases 9; MMP14: The matrix metalloproteinases 14; PARP: poly ADP-ribose polymerase; EMT, Epithelial-Mesenchymal Transition; ZEB1, zinc finger E-box binding homeobox 1; MAPK: Mitogen-activated protein kinase; ERK: extracellular signal-regulated kinase; JNK: Jun N-terminal kinases; CDK4: cyclin-dependent kinase 4; CDK6: cyclin-dependent kinase 6; NA, Not Available