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Table 1 – Demographics

From: Survival outcomes in men with a positive family history of prostate cancer: a registry based study

Variable   Family History  
   No Yes p
n   8801 658  
Age at diagnosis (median (IQR))   69[62,76] 63[57,69] < 0.001
PSA at diagnosis (%) 1. < 4 624 (7.1) 65 (9.9) < 0.001
  2. 4–10 3156 (35.9) 333 (50.6)  
  3. 10–20 1644 (18.7) 119 (18.1)  
  4. > 20 1395 (15.9) 59 (9.0)  
  5. Missing 1982 (22.5) 82 (12.5)  
Gleason Score at biopsy (%) < 7 3465 (39.4) 336 (51.1) < 0.001
  3 + 4 1805 (20.5) 152 (23.1)  
  4 + 3 1062 (12.1) 73 (11.1)  
  8 799 (9.0) 39 (6.1)  
  8+ 678 (7.6) 20 (3.1)  
  Missing 982 (11.2) 36 (5.5)  
NCCN Risk classification (%) High 519 (12.2) 32 (7.3) 0.005
  Intermediate 430 (10.1) 38 (8.7)  
  Low 3313 (77.7) 366 (83.9)  
Reason for Biopsy (%) 1. Elevated PSA 4626 (52.6) 451 (68.5) < 0.001
  2. Prostate Symptoms 1770 (20.1) 96 (14.6)  
  3. Other Symptoms 520 (5.9) 76 (11.6)  
  4. Not Known 1885 (21.4) 35 (5.3)  
Treatment year (%) < 2005 1399 (20.0) 83 (13.8) < 0.001
  > = 2005 5606 (80.0) 518 (86.2)  
Treatment group (%) Hormones 1113 (12.6) 36 (5.5) < 0.001
  Other 2234 (25.4) 89 (13.5)  
  Not yet classified 18 (0.2) 1 (0.2)  
  Radical Prostatectomy 2949 (33.5) 293 (44.5)  
  Radiation therapy 2487 (28.3) 239 (36.3)  
M stage at diagnosis (%) M0 1263 (96.7) 118 (99.2) 0.229
  M1 43 (3.3) 1 (0.8)  
N stage at diagnosis (%) N0 836 (97.2) 87 (98.9) 0.566
  N1 24 (2.8) 1 (1.1)  
Family members reported to have a positive history
 Grandfather (%) No 7811 (100.0) 634 (96.4) < 0.001
  Yes 0 (0.0) 24 (3.6)  
 Parent (%) No 7811 (100.0) 372 (56.5) < 0.001
  Yes 0 (0.0) 286 (43.5)  
 Sibling (%) No 7811 (100.0) 438 (66.6) < 0.001
  Yes 0 (0.0) 220 (33.4)  
 Child (%) No 7811 (100.0) 653 (99.2) < 0.001
  Yes 0 (0.0) 5 (0.8)  
 Grandchild (%) No 7811 (100.0) 658 (100.0) NA
 Uncle (%) No 7811 (100.0) 606 (92.1) < 0.001
  Yes 0 (0.0) 52 (7.9)  
 Cause of death (%) Not prostate cancer 1482 (57.8) 52 (55.9) 0.795
  Prostate cancer 1081 (42.2) 41 (44.1)