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Table 1 – Demographics

From: Survival outcomes in men with a positive family history of prostate cancer: a registry based study

Variable

 

Family History

 
  

No

Yes

p

n

 

8801

658

 

Age at diagnosis (median (IQR))

 

69[62,76]

63[57,69]

< 0.001

PSA at diagnosis (%)

1. < 4

624 (7.1)

65 (9.9)

< 0.001

 

2. 4–10

3156 (35.9)

333 (50.6)

 
 

3. 10–20

1644 (18.7)

119 (18.1)

 
 

4. > 20

1395 (15.9)

59 (9.0)

 
 

5. Missing

1982 (22.5)

82 (12.5)

 

Gleason Score at biopsy (%)

< 7

3465 (39.4)

336 (51.1)

< 0.001

 

3 + 4

1805 (20.5)

152 (23.1)

 
 

4 + 3

1062 (12.1)

73 (11.1)

 
 

8

799 (9.0)

39 (6.1)

 
 

8+

678 (7.6)

20 (3.1)

 
 

Missing

982 (11.2)

36 (5.5)

 

NCCN Risk classification (%)

High

519 (12.2)

32 (7.3)

0.005

 

Intermediate

430 (10.1)

38 (8.7)

 
 

Low

3313 (77.7)

366 (83.9)

 

Reason for Biopsy (%)

1. Elevated PSA

4626 (52.6)

451 (68.5)

< 0.001

 

2. Prostate Symptoms

1770 (20.1)

96 (14.6)

 
 

3. Other Symptoms

520 (5.9)

76 (11.6)

 
 

4. Not Known

1885 (21.4)

35 (5.3)

 

Treatment year (%)

< 2005

1399 (20.0)

83 (13.8)

< 0.001

 

> = 2005

5606 (80.0)

518 (86.2)

 

Treatment group (%)

Hormones

1113 (12.6)

36 (5.5)

< 0.001

 

Other

2234 (25.4)

89 (13.5)

 
 

Not yet classified

18 (0.2)

1 (0.2)

 
 

Radical Prostatectomy

2949 (33.5)

293 (44.5)

 
 

Radiation therapy

2487 (28.3)

239 (36.3)

 

M stage at diagnosis (%)

M0

1263 (96.7)

118 (99.2)

0.229

 

M1

43 (3.3)

1 (0.8)

 

N stage at diagnosis (%)

N0

836 (97.2)

87 (98.9)

0.566

 

N1

24 (2.8)

1 (1.1)

 

Family members reported to have a positive history

 Grandfather (%)

No

7811 (100.0)

634 (96.4)

< 0.001

 

Yes

0 (0.0)

24 (3.6)

 

 Parent (%)

No

7811 (100.0)

372 (56.5)

< 0.001

 

Yes

0 (0.0)

286 (43.5)

 

 Sibling (%)

No

7811 (100.0)

438 (66.6)

< 0.001

 

Yes

0 (0.0)

220 (33.4)

 

 Child (%)

No

7811 (100.0)

653 (99.2)

< 0.001

 

Yes

0 (0.0)

5 (0.8)

 

 Grandchild (%)

No

7811 (100.0)

658 (100.0)

NA

 Uncle (%)

No

7811 (100.0)

606 (92.1)

< 0.001

 

Yes

0 (0.0)

52 (7.9)

 

 Cause of death (%)

Not prostate cancer

1482 (57.8)

52 (55.9)

0.795

 

Prostate cancer

1081 (42.2)

41 (44.1)