Fig. 6

Cisplatin-resistant A2780cis cells show relative resistance to statins and zoledronic acid (ZOL) compared to parental A2780 cells. A2780 and A2780cis cells were treated with increasing concentrations of atorvastatin (ATO), simvastatin (SIM), rosuvastatin (ROSU) or (ZOL) for 48 h. Cell vitality (a) and apoptosis (b) were assessed by CellTiterBlue® and Caspase 3/7 Glo® assays. Statistics refers to A2780cis cells. Data are shown as mean ± SEM of at least three individual experiments. (*p < 0.05; **p < 0.01; ***p < 0.001 vs. respective control (0 μM). #p < 0.05; ##p < 0.01; ###p < 0.001 vs. respective value of A2780 treated cells)