Fig. 5
From: Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer
Statins reduce the expression of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β1 in IGROV-1 and A2780 cells. IGROV-1 (a) and A2780 (b) cells were treated with increasing concentrations of atorvastatin (ATO), simvastatin (SIM), rosuvastatin (ROSU) or zoledronic acid (ZOL). Expression of VEGF (24 h) and TGFβ1 (48 h) was assessed by quantitative real-time-PCR. Data are shown as mean ± SEM of at least three individual experiments. (*p < 0.05; **p < 0.01; ***p < 0.001 vs. respective control (0 μM))