Table 1 The optimum prognostic signature DERs identified by L1 penalized estimation based Cox-Proportional Hazards (Cox-PH) model
From: Prognosis prediction model based on competing endogenous RNAs for recurrence of colon adenocarcinoma
Symbol | Chromosome location | Type | Multi-variate Cox regression analysis | Lasso coefficient | ||
|---|---|---|---|---|---|---|
HR | 95%CI | P value | ||||
Protective RNAs | ||||||
 hsa-mir-105-1 | Xq28 | miRNA | 0.629 | 0.444–0.891 | 4.990E-02 | −0.034 |
 hsa-mir-3609 | 7q22.1 | miRNA | 0.635 | 0.486–0.831 | 9.340E-04 | −0.394 |
 MMAA | 4q31.21 | mRNA | 0.680 | 0.475–0.974 | 3.520E-02 | −0.781 |
Risky RNAs | ||||||
 LINC00115 | 1p36.33 | lncRNA | 1.692 | 1.103–2.595 | 1.602E-02 | 0.238 |
 NCBP2-AS1 | 3q29 | lncRNA | 2.121 | 1.450–3.104 | 1.080E-04 | 0.122 |
 hsa-mir-34c | 11q23.1 | miRNA | 1.150 | 1.013–1.304 | 3.019E-02 | 0.039 |
 hsa-mir-363 | Xq26.2 | miRNA | 1.250 | 1.121–1.395 | 6.490E-05 | 0.243 |
 hsa-mir-4709 | 14q24.3 | miRNA | 1.480 | 1.200–1.825 | 2.510E-04 | 0.635 |
 hsa-mir-891a | Xq27.3 | miRNA | 1.165 | 1.028–1.320 | 1.695E-02 | 0.196 |
 ALOX15 | 17p13.2 | mRNA | 1.495 | 1.229–1.818 | 5.660E-05 | 0.395 |
 ERVMER34–1 | 4q12 | mRNA | 1.259 | 1.058–1.497 | 9.378E-03 | 0.305 |
 GRAP | 17p11.2 | mRNA | 1.782 | 1.242–2.556 | 1.704E-03 | 0.542 |
 KCP | 7q32.1 | mRNA | 1.258 | 1.158–1.652 | 9.050E-03 | 0.231 |
 NKAIN4 | 20q13.33 | mRNA | 2.221 | 1.396–3.533 | 7.510E-04 | 0.220 |
 PADI1 | 1p36.13 | mRNA | 1.326 | 1.159–1.517 | 3.970E-05 | 0.373 |
 SIX4 | 14q23.1 | mRNA | 1.543 | 1.026–2.319 | 3.713E-02 | 0.423 |
 SLC16A8 | 22q13.1 | mRNA | 2.161 | 1.303–3.583 | 2.821E-03 | 0.881 |