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Table 3 Quality of life assessment based on EORTC-QLQ-C30

From: A prospective, randomized study of Toremifene vs. tamoxifen for the treatment of premenopausal breast cancer: safety and genital symptom analysis

EORTC-QLQ-C30 scales

Baseline

p-value

6-months follow-up

p-value

12-months follow-up

p-value

Toremifene

Tamoxifen

Toremifene

Tamoxifen

Toremifene

Tamoxifen

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Mean (SD)

Functional scales

 Physical functioning

86.05(12.75)

83.58(11.56)

0.276

88.68(12.13)

88.33(13.46)

0.968

90.10(11.36)

91.25(9.79)

0.849

 Role functioning

73.64(21.59)

79.27(20.68)

0.211

84.50(20.70)

81.48(21.37)

0.427

89.05(17.59)

86.46(16.09)

0.361

 Emotional functioning

70.93(20.92)

81.71(18.75)

0.017

76.16(22.76)

80.56(13.21)

0.667

79.76(19.83)

82.81(13.04)

0.798

 Cognitive functioning

82.56(18.17)

88.62(12.04)

0.138

83.72(16.46)

85.19(13.08)

0.932

84.29(21.37)

84.90(18.14)

0.825

 Social functioning

72.48(22.97)

78.46(20.50)

0.291

82.17(20.70)

85.64(19.17)

0.469

89.52(15.17)

87.50(16.40)

0.543

Symptom scales

 Fatigue

31.52(19.39)

25.20(14.70)

0.080

25.06(19.86)

25.00(14.64)

0.763

23.17(24.16)

18.75(16.80)

0.664

 Nausea/vomitting

3.10(11.65)

5.28(13.14)

0.198

3.10(8.34)

1.39(6.14)

0.229

1.90(6.73)

2.08(7.02)

0.909

 Pain

22.87(22.13)

16.67(13.94)

0.292

17.44(18.17)

12.5(14.57)

0.215

12.38(13.61)

16.15(16.11)

0.368

 Dyspnoea

18.60(28.45)

12.19(17.89)

0.211

13.18(20.75)

12.04(16.24)

0.924

15.24(21.91)

15.63(20.71)

0.850

 Insomnia

13.17(25.34)

28.46(26.42)

0.353

30.23(34.74)

28.70(21.31)

0.620

30.48(33.70)

23.96(25.73)

0.571

 Appetite loss

18.60(28.45)

9.76(17.07)

0.200

14.73(22.19)

5.56(12.60)

0.051

11.43(19.71)

5.21(12.30)

0.180

 Constipation

13.18(25.34)

12.20(19.37)

0.655

16.28(28.52)

6.49(17.49)

0.080

19.82(33.75)

13.54(20.50)

0.845

 Diarrhoea

6.20(13.12)

7.32(19.02)

0.898

3.88(10.81)

5.56(14.91)

0.733

4.50(16.03)

2.08(8.20)

0.728

  1. *p < 0.05 was considered statistically significant