EORTC-QLQ-C30 scales | Baseline | p-value | 6-months follow-up | p-value | 12-months follow-up | p-value | |||
---|---|---|---|---|---|---|---|---|---|
Toremifene | Tamoxifen | Toremifene | Tamoxifen | Toremifene | Tamoxifen | ||||
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||||
Functional scales | |||||||||
 Physical functioning | 86.05(12.75) | 83.58(11.56) | 0.276 | 88.68(12.13) | 88.33(13.46) | 0.968 | 90.10(11.36) | 91.25(9.79) | 0.849 |
 Role functioning | 73.64(21.59) | 79.27(20.68) | 0.211 | 84.50(20.70) | 81.48(21.37) | 0.427 | 89.05(17.59) | 86.46(16.09) | 0.361 |
 Emotional functioning | 70.93(20.92) | 81.71(18.75) | 0.017 | 76.16(22.76) | 80.56(13.21) | 0.667 | 79.76(19.83) | 82.81(13.04) | 0.798 |
 Cognitive functioning | 82.56(18.17) | 88.62(12.04) | 0.138 | 83.72(16.46) | 85.19(13.08) | 0.932 | 84.29(21.37) | 84.90(18.14) | 0.825 |
 Social functioning | 72.48(22.97) | 78.46(20.50) | 0.291 | 82.17(20.70) | 85.64(19.17) | 0.469 | 89.52(15.17) | 87.50(16.40) | 0.543 |
Symptom scales | |||||||||
 Fatigue | 31.52(19.39) | 25.20(14.70) | 0.080 | 25.06(19.86) | 25.00(14.64) | 0.763 | 23.17(24.16) | 18.75(16.80) | 0.664 |
 Nausea/vomitting | 3.10(11.65) | 5.28(13.14) | 0.198 | 3.10(8.34) | 1.39(6.14) | 0.229 | 1.90(6.73) | 2.08(7.02) | 0.909 |
 Pain | 22.87(22.13) | 16.67(13.94) | 0.292 | 17.44(18.17) | 12.5(14.57) | 0.215 | 12.38(13.61) | 16.15(16.11) | 0.368 |
 Dyspnoea | 18.60(28.45) | 12.19(17.89) | 0.211 | 13.18(20.75) | 12.04(16.24) | 0.924 | 15.24(21.91) | 15.63(20.71) | 0.850 |
 Insomnia | 13.17(25.34) | 28.46(26.42) | 0.353 | 30.23(34.74) | 28.70(21.31) | 0.620 | 30.48(33.70) | 23.96(25.73) | 0.571 |
 Appetite loss | 18.60(28.45) | 9.76(17.07) | 0.200 | 14.73(22.19) | 5.56(12.60) | 0.051 | 11.43(19.71) | 5.21(12.30) | 0.180 |
 Constipation | 13.18(25.34) | 12.20(19.37) | 0.655 | 16.28(28.52) | 6.49(17.49) | 0.080 | 19.82(33.75) | 13.54(20.50) | 0.845 |
 Diarrhoea | 6.20(13.12) | 7.32(19.02) | 0.898 | 3.88(10.81) | 5.56(14.91) | 0.733 | 4.50(16.03) | 2.08(8.20) | 0.728 |