The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma

Table 2 Analysis of the association of ALDH1A3 IRS with clinical parameters

Clinical parameter	Patient number	ALDH1A3		P
Clinical parameter	Patient number	negative/low (IRS ≤ 2)	medium/high (IRS > 2)	P
Total patients	30	15	15
Age				0,456^a
< 60	12	7	5
≥ 60	18	8	10
Gender				0,464^a
Male	14	6	8
Female	16	9	7
KPI				1,000^b
≥ 70	26	13	13
< 70	4	2	2
SVZ				0,121^a
+	20	12	8
−	10	3	7
Extent of Resection				0,456^a
GTR	18	8	10
Partial	12	7	5
MGMT promotor methylation				0,464^a
Yes	14	6	8
No	14	9	7
N/A	2	1	1
IDH1 mutation				0,270^b
Yes	3	2	1
No	17	5	12
N/A	10	8	2
Standard chemoradiotherapy				0,256^a
Yes	19	11	8
No	11	4	7
Ki67 index (%)	27	16,3 ± 3,1 (n = 12)	17,3 ± 2,0 (n = 15)	0,789^c

IRS immunoreactive score, KPI Karnofsky Performance Index, SVZ +/− tumor contacted to subventricular zone (SVZ+) or contacted to non-subventricular zone (SVZ−), GTR gross total resection, MGMT O6-methylguanine-methyltransferase, IDH1 isocitrate dehydrogenase 1, N/A not applicable
^aPearson chi-square test; ^bFisher’s exact test; ^cStudent t test with Welch’s correction

ISSN: 1471-2407