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Table 2 Association between MEG3 gene polymorphisms and risk of breast cancer (rs11160608, rs3087918, rs7158663)

From: LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

SNPs genetic model Genotype Cases (%)
N = 434
Controls (%)
N = 700
OR (95%CI) P value
rs11160608
 Co-dominant AA 126 (29.7) 227 (32.4) reference  
AC 218 (51.4) 341 (48.7) 1.15 (0.87–1.52) 0.316
CC 80 (18.9) 132 (18.9) 1.09 (0.77–1.55) 0.625
 Dominant AA 126 (29.7) 227 (32.4) reference  
AC + CC 298 (70.3) 473 (67.6) 1.14 (0.87–1.48) 0.342
 Recessive AA+AC 344 (81.1) 568 (81.1) reference  
CC 80 (18.9) 132 (18.9) 1.00 (0.74–1.36) 0.996
 Allele A 470 (55.4) 795 (56.8) reference  
C 378 (44.6) 605 (43.2) 1.06 (0.89–1.26) 0.528
rs3087918
 Co-dominant TT 171 (40.2) 259 (37.0) reference  
TG 207 (48.7) 334 (47.7) 0.94 (0.72–1.22) 0.633
GG 47 (11.1) 107 (15.3) 0.67 (0.45–0.99) 0.042*
 Dominate TT 171 (40.2) 259 (37.0) reference  
TG + GG 254 (59.8) 441 (63.0) 0.87 (0.68–1.12) 0.279
 Recessive TT + TG 378 (88.9) 593 (84.7) reference  
GG 47 (11.1) 107 (15.3) 0.69 (0.48–0.99) 0.046*
 Allele T 549 (64.6) 852 (60.9) reference  
G 301 (35.4) 548 (39.1) 0.85 (0.71–1.02) 0.077
rs7158663
 Co-dominate GG 224 (52.5) 403 (0.6) reference  
GA 170 (39.8) 250 (0.4) 1.22 (0.95–1.58) 0.12
AA 33 (7.7) 47 (0.1) 1.26 (0.79–2.03) 0.333
 Dominate GG 224 (52.5) 403 (0.6) reference  
GA + AA 203 (47.5) 297 (0.4) 1.23 (0.97–1.57) 0.094
 Recessive GG + GA 394 (92.3) 653 (0.9) reference  
AA 33 (7.7) 47 (0.1) 1.16 (0.73–1.85) 0.52
 Allele G 618 (72.4) 1056 (75.4) reference  
A 236 (27.6) 344 (24.6) 1.17 (0.97–1.42) 0.107
  1. OR: odds ratio, CI: confidence interval
  2. *The P Value < 0.05