Table 5 Treatment outcome of severe irAE patients
organ | irAE detail | grade | origin | time to last ICI | Time to first ICI | treatment | outcome | reteatment | complication | preexisting antibody |
|---|---|---|---|---|---|---|---|---|---|---|
skin | whole body prurigo | 3 | lung | 21 | 69 | steroid po&ointment | remission | try | none | RF |
skin | whole body prurigo | 3 | lung | 12 | 12 | steroid po,ointment &iv | remission | stop | none | TgAb,TPO,RF, ANA |
Liver | elevated liver enzyms | 3 | renal | 21 | 21 | steroid po | remission | PD | none | ANA |
pneumonitis | interstitial pneumonia | 4 | lung | 3 | 3 | systemic pulse steroid | death | stop | dyalisis, lymphangitis | ANA |
pneumonitis | interstitial pneumonia | 4 | gastric | 16 | 140 | systemic pulse steroid | death | PD | none | |
pneumonitis | interstitial pneumonia | 3 | lung | 7 | 31 | systemic pulse steroid | PD | none | ||
CNS | convulsion | 5 | malignant melanoma | 17 | 43 | systemic pulse steroid | death | stop | brain meta RTx | |
thyroid | hyposthenia | 3 | gastric | 10 | 68 | steroid po | remission | try | none | ANA |