Table 1 Characteristics of patients with and without irAE
with irAE(n = 115) | without irAE(n = 165) | p value | |
|---|---|---|---|
Age median (range) | 69.7 (43–88) | 66.0 (22–87) | 0.2 |
Sex (male/female) | 90/25 | 119/46 | 0.25 |
ECOG PS, 0/1/> 2 | 69/42/4 | 101/58/6 | |
preexisting autoimmune disease | 10 | 14 | 0.26 |
past regimen line (%) | |||
1st | 27 (23.5) | 24 (14.5) | |
2nd | 43 (37.4) | 47 (28.5) | |
3rd | 30 (26.1) | 62 (37.6) | |
4th~ | 15 (13.0) | 32 (19.4) | |
origin number (%) | |||
gastric | 15 (13) | 44 (26.7) | p = 0.03 |
lung | 68 (59.1) | 61 (36.9) | |
RCC, urothelial and bladder cancer | 19 (16.5) | 28 (17) | |
malignant melanoma | 5 (4.3) | 8 (4.8) | |
head and neck | 7 (6.1) | 19 (11.5) | |
reccurent Hodgikin lymphoma | 1 (0.9) | 1 (0.6) | |
malignant pleural mesothelioma | 0 (0) | 4 (2.4) | |
Best Response (number) | |||
CR | 1 | 1 | |
PR | 37 | 20 | |
SD | 45 | 44 | |
PD | 32 | 98 | |
ORR(%) | 33 | 12.7 | < 0.001 |
DCR(%) | 72.2 | 38.2 | < 0.001 |